David Rosen, M.D., Ph.D.

Assistant Professor

Molecular Microbiology and Microbial Pathogenesis Program
Immunology Program

  • 314 286-1821

  • 314 273-2810

  • 6th Floor, McDonnell Pediatric Research Building

  • rosend@wustl.edu

  • http://research.peds.wustl.edu/labs/rosen_d

  • Klebsiella pneumoniae, Antibiotic Resistance, Pneumonia, Urinary Tract Infection, Virulence Factors, Adaptive Immunity

  • Pathogenesis and host response to Klebsiella pneumoniae infections

Research Abstract:

Our lab focuses on the pathogenesis of Klebsiella pneumoniae, an increasingly resistant and versatile organism. One of only three threats deemed "urgent" by the CDC, resistant Klebsiella infections kill half of people afflicted and are only increasing in prevalence. Utilizing mouse models of pneumonia and urinary tract infection (UTI), we are dissecting just how this bacterium causes infection in the host. While our antibiotics may not be successful in killing this pathogen, we are striving to develop methods by which to inhibit virulence of the organism.

Mentorship and Commitment to Diversity Statement:
I am committed to working with and training engaged scientists from all backgrounds, cultures, races and orientations. We are accepting of all religions, political affiliations and viewpoints, fostering an environment of open dialogue.  Together, we will accomplish great advancements by following the data to scientific success.

Selected Publications:

Rosen DA, Twentyman J, Hunstad DA. High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. Infect Immun. 2018;86(2). PMCID:PMC5778367 PMID:29158434

Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016;213(4):649-658. PMCID:PMC4721909 PMID:26347570

Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ. Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun. 2008;76(7):3337-45. PMCID:PMC2446714 PMID:18411285

Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ. Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun. 2008;76(7):3346-56. PMCID:PMC2446687 PMID:18474655

Rosen DA, Hung CS, Kline KA, Hultgren SJ. Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun. 2008;76(9):4290-8. PMCID:PMC2519435 PMID:18644886

Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med. 2007;4(12):e329. PMCID:PMC2140087 PMID:18092884

Last Updated: 3/22/2021 1:54:30 PM

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