Bahaa E. Elgendy, Ph.D.

Assistant Professor
Anesthesiology
Center for Clinical Pharmacology

Biochemistry, Biophysics, and Structural Biology Program
Computational and Systems Biology Program

  • belgendy@wustl.edu

  • Medicinal chemistry with a broad goal of drug design and organic synthesis

Research Abstract:

The main focus of Dr. Elgendy’s research group is drug design and organic synthesis. He designs and synthesize novel small organic molecules as modulators of nuclear hormone receptors for the therapeutic treatment of cancer, fatty liver diseases, Alzheimer’s Disease, and Atherosclerosis. Also, he synthesizes complex and diverse molecules to combat multi-drug resistant bacteria and anti-viral agents against HCV and ZIKV and other microbes. Dr. Elgendy incorporates computational methods such as quantitative structure activity relationships, pharmacophore modeling, and virtual screening in his drug discovery pipeline to accelerate the process of drug discovery and optimization.

Selected Publications:

Elagawany M, Hegazy L, Elgendy B. Catalyst- and organic solvent-free synthesis of thioacids in water. Tetrahedron Letters. 2019 June; 60(30):2018. doi: https://doi.org/10.1016/j.tetlet.2019.06.061.

Elagawany M, Farid NF, Elgendy B, Abdelmomen EH, Abdelwahab NS. Baclofen Impurities: Facile Synthesis and Novel Environmentally Benign Chromatographic Method for their Simultaneous Determination in Baclofen. Biomed Chromatogr. 2019 May 11;:e4579.

Goher SS, Griffett K, Hegazy L, Elagawany M, Arief MMH, Avdagic A, Banerjee S, Burris TP, Elgendy B. Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold. Bioorg Med Chem Lett. 2019 Feb 1;29(3):449-453.

El-Gendy BEM, Goher SS, Hegazy LS, Arief MMH, Burris TP. Recent Advances in the Medicinal Chemistry of Liver X Receptors. J Med Chem. 2018 Dec 27;61(24):10935-10956.

Cao F, Orth C, Donlin MJ, Adegboyega P, Meyers MJ, Murelli RP, Elagawany M, Elgendy B, Tavis JE. Synthesis and Evaluation of Troponoids as a New Class of Antibiotics. ACS Omega. 2018 Nov 30;3(11):15125-15133.

Elagawany M, Hegazy L, Cao F, Donlin MJ, Rath N, Tavis J, Elgendy B. Identification of 4-isopropyl–thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation. RSC advances. 2018 August; 8:29967.

Last Updated: 8/14/2019 2:00:24 PM

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