F. Matthew Kuhlmann, M.D.

Assistant Professor
Internal Medicine
Infectious Diseases

Molecular Microbiology and Microbial Pathogenesis Program

  • fkuhlman@wustl.edu

  • The pre-clinical development of rationally designed Enterotoxigenic E. coli (ETEC) vaccines

Research Abstract:

My research supports the pre-clinical development of rationally designed Enterotoxigenic E. coli (ETEC) vaccines. Having recently completed a Masters of Science in Clinical Investigation, I was able to combine basic science observations with the EtpA lectin of ETEC with human trial data to demonstrate that host blood type influences disease severity. Further studies on the molecular epidemiology, genomic, and functional conservation of candidate antigens from a globally diverse collection of ETEC from symptomatic individuals support their inclusion in vaccine development. Current funding also supports translational studies probing the interaction of blood type, the immune response, and ETEC infections in Bangladesh. This work demonstrates the importance of understanding unique host-pathogen interactions to develop improved vaccine strategies.

Selected Publications:

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.
Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.
J Clin Invest. 2019 Jul 1;129(7):2980.

Enterotoxigenic Escherichia coli Infections.
Fleckenstein JM, Kuhlmann FM.
Curr Infect Dis Rep. 2019 Mar 4;21(3):9.

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.
Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.
J Clin Invest. 2018 Aug 1;128(8):3298-3311.

Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.
Rossi M, Castiglioni P, Hartley MA, Eren RO, Prével F, Desponds C, Utzschneider DT, Zehn D, Cusi MG, Kuhlmann FM, Beverley SM, Ronet C, Fasel N.
Proc Natl Acad Sci U S A. 2017 May 9;114(19):4987-4992.

Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.
Castiglioni P, Hartley MA, Rossi M, Prevel F, Desponds C, Utzschneider DT, Eren RO, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann FM, Beverley SM, Fasel N, Ronet C.
PLoS Negl Trop Dis. 2017 Jan 18;11(1):e0005240.

Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.
Kuhlmann FM, Robinson JI, Bluemling GR, Ronet C, Fasel N, Beverley SM.
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E811-E819

Last Updated: 8/14/2019 2:00:57 PM

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