Jai S. Rudra, Ph.D.

Assistant Professor
Biomedical Engineering

Molecular Microbiology and Microbial Pathogenesis Program

  • srudra22@wustl.edu

  • https://rudralab.wustl.edu/

  • Development of nano-scale biomaterials for engaging the immune system to induce protective antibody and cell-mediated immune responses against diseases

Research Abstract:

Jai Rudra's lab is interested in the development of nano-scale biomaterials such as nanofibers, nanoparticles, virus-like particles, and hydrogels for engaging the immune system to induce protective antibody and cell-mediated immune responses against diseases such as tuberculosis, melanoma and flavivirus infections (West Nile and Zika). His is also investigating the development of vaccines against drugs of addiction such as cocaine.

Biomaterials immunoengineering is a multidisciplinary field that lies at the intersection of materials science, chemistry, immunology and vaccinology. His lab collaborates with virologists, immunologists, and clinicians not only to develop synthetic vaccination platforms but also to understand how biomaterials interact with the immune system and continue to develop novel materials and creative tools to tackle multidisciplinary problems in vaccine development and immunotherapy.

Selected Publications:

Chesson, C. B., Huante, M., Nusbaum, R. J., Walker, A. G., Clover, T. M., Chinnaswamy, J.,...Rudra, J. S. (2018). Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity Against Mycobacterium tuberculosis. Scientific Reports, 8(1), 12519.

Chesson, C.B., Alvarado, R. E., & Rudra, J. S. (2018). Microwave-Assisted Synthesis and Immunological Evaluation of Self-Assembling Peptide Vaccines BT - Peptide Self-Assembly: Methods and Protocols. In B. L. Nilsson & T. M. Doran (Eds.) (pp. 249–259). New York, NY: Springer New York.

Scala, F., Nenov, M. N., Crofton, E. J., Singh, A. K., Folorunso, O., Zhang, Y.,...Laezza, F. (2018). Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway. Cell Reports, 23(2), 555-567.

Chesson, C. B., Ekpo-Otu, S., Endsley, J. J., & Rudra, J. S. (2017). Biomaterials-Based Vaccination Strategies for the Induction of CD8+T Cell Responses. ACS Biomaterials Science & Engineering, 3(2), 126-143.

Rudra, J. S., Khan, A., Clover, T. M., Endsley, J. J., Zloza, A., Wang, J., & Jagannath, C. (2017). Supramolecular Peptide Nanofibers Engage Mechanisms of Autophagy in Antigen-Presenting Cells. ACS Omega, 2(12), 9136-9143.

Last Updated: 1/13/2020 1:13:56 PM

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