Stefanie Geisler, M.D.

Assistant Professor
Neurology

Neurosciences Program

  • geislers@wustl.edu

  • Elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies

Research Abstract:

Dr. Geisler’s laboratory research focuses on elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies. The translational goal is to find treatments to prevent axonal degeneration and facilitate regeneration.

Selected Publications:

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040.

Geisler S, Doan R, Cheng G, Cetinkaya-Fisgin A, Huang S, Höke A, Milbrandt J, DiAntonio A. Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. JCI Insight. 2019; 4(17):-. doi: 10.1172/jci.insight.129920.

Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain. 2016 Dec;139(Pt 12):3092-3108. doi: 10.1093/brain/aww251.

Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016.

Shin JE, Geisler S, DiAntonio A. Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol. 2014 Feb;252:1-11. doi: 10.1016/j.expneurol.2013.11.007.

Last Updated: 12/15/2019 2:16:22 PM

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