Peggy L. Kendall, MD

Associate Professor
Internal Medicine
Allergy & Pulmonary

Immunology Program

  • 8122

  • peggy.kendall@wustl.edu

  • The role of B lymphocytes in autoimmune disease

Research Abstract:

Dr. Kendall’s research focuses on the role of B lymphocytes in autoimmune disease. Specific research interests include determining how B cell signaling mediated by Bruton’s tyrosine kinase contributes to autoimmune disease, including inflammatory arthritis and type 1 diabetes, as well as the relationship with the inflammatory microbiome.

Dr. Kendall is also investigating the role of immune cells as biomarkers and therapeutic targets of lung disease in patients with idiopathic pulmonary fibrosis and systemic sclerosis with and without interstitial lung disease.

Selected Publications:

1. Kendall, P.L., Woodward, E.J., Yu, G., Thomas, J.W. Tertiary Lymphoid Structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. J. Immunol. 2007;178(9):5643-5651.

2. Kendall, P.L.*, Moore, D.J., Hulbert, C., Hoek, K.L., Khan, W.N., Thomas, J.W. Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. J Immunol. 2009;183(10):6403-6412, 2009. *Corresponding author.

3. Kendall, P.L.*, Case J.B., Sullivan, A.M., Holderness J.S., Wells, K.S., Liu, E., and Thomas, J.W. Tolerant anti-insulin B cells are effective APCs. J. Immunol. 2013;190(6):2519-26. (Faculty of 1000 recommended). *Corresponding author.

4. Henry, R.H., Sullivan, A.M., Case, J.B., Steinberg, H.E., Hoek, K.L., Khan, W.N., Kendall, P.L. Bruton’s Tyrosine Kinase promotes persistence of mature anti-insulin B cells. J Immunol. 2014;192(4):1459-70.

5. Nyhoff, L.E., Barron, B., Johnson, E.M., Bonami, E.H., Maseda, D., Han, W., Blackwell, T.S., Crofford, L., Kendall, P.L. Bruton’s tyrosine kinase deficiency inhibits autoimmune arthritis but fails to block immune complex mediated inflammatory arthritis. Arthritis & Rheumatol. 2016;68(8):1856-68.

6. Crofford, L.J., Nyhoff, L.E., Sheehan, J.H., and Kendall, P.L. The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy. Expert Review of Clinical Immunology, 2016;12(7):763-73.

7. Nyhoff L.E., Clark, E.S., Barron, B.L., Bonami, R.H., Khan W.N., Kendall, P.L. Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages. J Immunol. 2018;200(7):2352-2361.

8. Wilfong, E.M., Lentz, R.J., Guttentag, A, Tolle, J.J., Johnson, J.E., Kropski, J.A., Kendall, P.L., Blackwell, T.S., and Crofford, L.J. Interstitial Pneumonia with Autoimmune Features: An emerging challenge at the intersection of rheumatology and pulmonology. Review. Arthritis and Rheumatology 2018 Dec;70(12):1901-1913

Last Updated: 12/13/2019 9:57:08 AM

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