Mohamed A. Zayed, M.D.,Ph.D.

Associate Professor
Surgery

Molecular Cell Biology Program
Cancer Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • zayedm@wustl.edu

  • The mechanisms that influence arterial collateral formation and peripheral arterial atheroprogression in the setting of diabetes

Research Abstract:

The Zayed Laboratory studies the mechanisms that influence arterial collateral formation and peripheral arterial atheroprogression in the setting of diabetes. We are interested in better understanding why diabetic patients have a significantly higher incidence of developing peripheral arterial disease (PAD) and are at increased risk of malperfusion at healing surgical sites. We hypothesize that arterial phospholipid tissue expression and processing play a central role in this process. Our team of scientists explores this using a complement of biochemical assays, in vivo animal models, and biobank of vascular tissue specimens. Our vascular clinical team translates its findings from bench-to-bedside through ongoing clinical research trials. Ultimately, our aim is to develop effective new therapeutic modalities for the treatment of diabetic patients with progressive PAD.

Selected Publications:

Desai K, Brownie E, Cook J, Zayed MA. Tulip Piercing the Aorta: A Rare Case of IVC Filter Aortic Perforation and Obstruction. J Surgery Case Rep, 2018 Oct 29;2018(10):rjy280. doi: 10.1093/jscr/rjy280.

Kuziez MS, Picus D, Sanchez L, Zayed MA. Trans-Luminal Repair of a Ruptured AAA with Type 1a and Type II Endoleaks. Journal of Surgical Case Reports, 2018 Oct 1;2018 (10): rjy254.

Edalati M, Hastings MK, Sorensen CJ, Zayed MA, Mueller MJ, Hildebolt CF, Zheng J. Diffusion Tensor Imaging of the Calf Muscles in Subjects With and Without Diabetes Mellitus. J Magn Reson Imaging Sept 2018. DOI: 10.1002/jmri.26286.

Holzem KM, Jayarajan S, Zayed MA. Surgical Planning with Three-Dimensional Printing of Complex Renal Artery Aneurysm. Journal of Vascular Surgery, Innov Tech 4(1):19, 2018.

Zayed MA, Hsu FF, Patterson BW, Yan Y, Naim U, Darwesh M, De Silva G, Yang C, Semenkovich CF. Diabetes Adversely Affects Phospholipid Profiles in Human Carotid Artery Endarterectomy Plaques. Journal of Lipid Research 59(4):730-38, 2018.

Garcia M, Gao S, Edmiston C, York T, Marinov R, Mondal S, Zhu N, Sudlow GP, Akers WJ, Margenthaler J, Liang R, Zayed MA, Pepino MY, Achilefu S, Gruev V. A Bioinspired Imager Improves Sensitivity for Near-Infrared Fluorescence Image-Guided Surgery. Optica 5(4): 413-22, 2018.

Yang C, Fang H, Yang Y, Cai F, Zheng H, Jin B, Li Y, Liu Z, Zayed MA. Diagnosis and Surgical Management of Inferior Vena Cava Leiomyomatosis. Journal of Vascular Surgery Venous Lymphatic Disorders 6(5): 636-45, 2018.

Last Updated: 1/13/2020 2:54:42 PM

Back To Top

Follow us: