Tao Che, Ph.D.

Assistant Professor
Anesthesiology

Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program
Neurosciences Program

  • 314-446-8016

  • STLCOP, Academic Research Building, Rm. 614

  • taoche@wustl.edu

  • http://chelab.wustl.edu/

  • GPCRs, Analgesics, Side effects, opioid receptors, opioids, opioid alternatives

  • Characterizing and dissecting the molecular mechanisms of opioid receptor signaling

Research Abstract:

Research in the Che lab will be aimed at comprehensively characterizing and dissecting the molecular mechanisms of opioid receptor signaling. The goal is to gain an atomic-level understanding of opioid receptor activation, and to use this information to develop chemical and synthetic biologic tools (e.g., nanobodies) to ultimately lead to the development of safer, non-addictive pain medications. His work will integrate structural (e.g., X-ray, Cryo-EM) and pharmacological approaches, and leverage these data to generate subtype-specific novel chemicals as in vivo precision pharmacology probes to understand opioid receptor signaling spatiotemporally. These will be useful probes to interrogate signaling pathways and provide a platform for the discovery of new chemical and biological matter for potential therapeutic applications.

Selected Publications:

Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, et al. Nanobody-enabled monitoring of kappa opioid receptor states. Nat Commun. 2020. PMID: 32123179.

Lyu JK, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O’Meara MJ, Che T, Algaa E, Tolmachev AA, Shoichet BK, Roth BL & Irwin JJ. Ultra-large library docking for new chemotypes. Nature. 2019. PMID: 30728502.

Che T, Roth BL. Phosphoproteomics Illuminates Opioid Actions. Biochemistry. 2018. PMID: 30179451.

Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL. Structure of the D 2 dopamine receptor bound to the atypical antipsychotic drug risperidone. Nature. 2018 Mar 8;555(7695):269-273. PMID: 29466326.

Peng Y, McCorvy JD, Harpsøe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, et al. 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell. 2018; PMID: 29398112.

Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, et alL. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. 2018;172(1-2):55-67.

Last Updated: 6/5/2020 10:49:36 AM

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