Vijay K. Samineni, Ph.D.

Assistant Professor
Anesthesiology

Neurosciences Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • 314 362-8795

  • vksamineni@wustl.edu

  • Intersection between visceral sensation, organ function, and emotions

Research Abstract:

The central goal of our laboratory is to study common tenets of how visceral organ function is regulated in the brain and how it influences emotional wellbeing. Our lab studies intersection between visceral sensation, organ function, and emotions. We are in pursuit of a comprehensive understanding of how the brain interprets, adapts, and responds to signals from the peripheral organs during normal and pathological states and how it shapes our emotions. We implement genetic, molecular, and neuroanatomical tools to study these questions across the nervous system to link genes, cells, circuits, and behavior.

We strive for excellence in science we do and believe in creating a supportive and inclusive environment regardless of race, background, or beliefs. We will be thrilled to offer opportunities to students and scientists from under-represented and disadvantaged groups to pursue scientific endeavors with our group.

Selected Publications:

1. Samineni VK, Grajales-Reyes JG, Sundaram SS, Yoo JJ, Gereau RW 4th.
Cell typespecific modulation of sensory and affective components of itch in the periaqueductal gray.
Nature Communications. Sep 2019. DOI: 10.1038/s41467-019-12316-0

2. Grajales-Reyes JG, Samineni VK
Untangling a canopy of spinal itch circuits.
Pain. May 2019. DOI: 10.1097/j.pain.0000000000001537

3. Mickle AD, Won SM, Noh KN, Yoon J, Meacham KM, Xue Y, McIlvried LA, Copits BA, Samineni VK, Crawford KE, Kim DH, Srivastava P, Kim BH, Min S, Shiuan Y, Yun Y, Zhang J, Jang H, Li Y, Lai HH, Huang Y, Park SI, Gereau RW 4th, Rogers JA.
A soft, wireless closed-loop neuromodulation system for treating bladder dysfunction.
Nature. Jan 2019. doi: 10.1038/s41586-018-0823-6.

4. Shepherd AJ., Mickle AD., Golden JP., Mack MR., Halabi CM., de Kloet AD., Samineni VK, Kim BS., Krause EG., Gereau RW 4th., and Mohapatra DP.
Macrophage angiotensin II type 2 receptor triggers neuropathic pain.
PNAS. Aug 2018 doi: 10.1073/pnas.1721815115.

5. Hibberd TJ, Feng J, Lou J, Yang P, Samineni VK, Gereau RW 4th, Spencer NJ, Hu H.
Optogenetic control of the enteric nervous system and induction of colonic motility generating increased transit of luminal content.
Gastroenterology. Aug 2018 doi: 10.1053/j.gastro.2018.05.029.

6. Carlin D, Golden JP, Mogha A, Samineni VK, Monk KR, Gereau RW 4th, Cavalli V.
Deletion of Tsc2 in nociceptors reduces target innervation, ion channel expression and sensitivity to heat.
eNeuro. May 2018. doi: 10.1523/ENEURO.0436-17.2018.

7. DeBerry JJ*, Samineni VK*, Copits BA, Sullivan CJ, Vogt SK, Albers KM, Davis BM, Gereau RW 4th.
Differential Regulation of Bladder Pain and Voiding Function by Sensory Afferent Populations Revealed by Selective Optogenetic Activation.
Front. Integr. Neurosci., Feb 2018 doi.org/10.3389/fnint.2018.00005. *co-first author

Last Updated: 2/9/2021 4:12:15 PM

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