Brian Laidlaw, Ph.D.

Assistant Professor
Internal Medicine

Immunology Program
Computational and Systems Biology Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-747-8499

  • 314-286-2858

  • Lab: Room 10301 / Office: Room 10615, BJC Institute of Health

  • brian.laidlaw@wustl.edu

  • www.laidlawlab.com

  • Brian Laidlaw@LaidlawLab

  • B cells, immunological memory, germinal center, virus, allergy

  • Investigating the development of immunological memory in disease states

Research Abstract:

The Laidlaw lab investigates the development of immunological memory in disease states. Specifically, we are focused on understanding the transcriptional networks regulating the development and function of memory B cells following viral infection. We use advanced mouse models, sequencing, and screening approaches to identify novels regulators of immune memory development and to determine the mechanisms by which these regulators function.

The overall goal of this research is to help facilitate the design of vaccines capable of eliciting a broadly protective immune response against highly mutable pathogens.

Selected Publications:

Laidlaw, B.J., Duan. L., Xu, Y., Vazquez, S.E., and Cyster, J. (2020) The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nat. Immunol. 21, 1082-1093. PMCID: PMC7442689

Laidlaw, B.J.*, and Cyster, J. (2020). Transcriptional regulation of memory B cell differentiation. Nat. Rev. Immunol. Accepted. *Corresponding Author

Gagnon, J.D., Kageyama, R., Shehata, H.M., Fassett, M.S., Mar, D., Wigton, E.J., Johannson, K., Litterman, A.J., Odorizzi, P., Simeonov, D., Laidlaw, B.J., …, Marson, A. Matloubian, M., Sanjabi, S., and Ansel, M. (2019) mir-15/16 restrain memory T cell differentiation, cell cycle, and survival. Cell Reports. 28 (8), 2169-2184. PMCID: PMC6715152

Laidlaw, B.J., Gray, E.E., Zhang, Y., Ramírez-Valle, F., and Cyster, J. (2019) Sphingosine-1 phosphate receptor 2 restrains egress of gd T cells from the skin. J. Exp. Med. 216 (7), 1487-1496.

Guan, T., Dominguez, C.X., Amezquita, R.A., Laidlaw, B.J., Cheng, J., Henao-Mejia, J., Williams, A., Flavell, R.A., Lu, J., and Kaech, S.M. (2018) ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8+ T cell fates. J. Exp. Med. 215 (4), 1153–1168. PMCID: PMC5881466

Weinstein, J.S., Laidlaw, B.J., Lu, Y., Wang, J., Shulz, V., Li, N., Herman, E.I., Kaech, S.M., Gallagher, P., and Craft, J. (2018) STAT4 and T-bet control follicular helper T cell development in viral infections. J. Exp. Med. 215 (1), 337-355. PMCID: PMC5748849

Last Updated: 10/22/2020 3:13:15 PM

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