Natalie M. Niemi, Ph.D

Assistant Professor
Biochemistry and Molecular Biophysics

Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program

  • niemi@wustl.edu

  • https://www.niemilab.com/

  • Understanding how mitochondria are built, regulated, and maintained

Research Abstract:

WHAT: The Niemi lab studies how mitochondria are made and coordinated across physiological contexts. Projects in the lab include understanding the mechanisms and regulation of mitochondrial biogenesis, determining how select mitochondrial proteins are targeted for degradation, and characterizing how post-translational modifications influence mitochondrial form and function.

HOW: We blend classic, hypothesis-driven biochemistry, discovery-based systems approaches, and mammalian physiology to understand mitochondria at the enzymatic, organellar, and whole-organism level.

WHY: Our long-term goal is to translate our discoveries into new therapeutics options that restore mitochondrial function in human disease.

Selected Publications:

Pptc7 is an essential phosphatase for promoting mitochondrial metabolism and biogenesis
Niemi, N.M., Wilson, G.M., Overmyer, K.A., Vogtle, F.N., Lohman D.C., Schueler, K.L., Attie, A.D., Meisinger C., Coon, J.J., and D.J. Pagliarini. 2019. Nat Commun. 10(1):3197. PMID: 31324765

Integrative Proteomics and Biochemical Analyses Define Ptc6p as the Saccharomyces cerevisiae Pyruvate Dehydrogenase Phosphatase
Guo X., Niemi N.M., Coon J.J., and D.J. Pagliarini. 2017. J. Biol. Chem. 292(28):11751-11759. PMID: 28539364

Ptc7p dephosphorylates select mitochondrial proteins to enhance metabolic function
Guo X.*, Niemi N.M.*, Hutchins, P.D., Condon, S.G.F., Jochem, A., Ulbrich, A., Higbee, A.J., Russell, J.D., Senes, A., Coon, J.J., and D.J. Pagliarini. 2017. Cell Rep. 18(2):307-13. *Co-first author. PMID: 28076776

A quantitative map of the liver mitochondrial phosphoproteome reveals post-translational control of ketogenesis
Grimsrud, P.A.*, Carson, J.J.*, Hebert, A.S., Hubler, S.L., Niemi, N.M., Bailey, D.J., Jochem, A., Stapleton, D.S., Keller, M.P., Westphall, M.S., Yandell, B.S., Attie, A.D., Coon, J.J., and D.J. Pagliarini. 2012. Cell Metab. 16(5): 672-83. *Co-first author

MK-STYX, a catalytically inactive phosphatase regulating mitochondrial dependent apoptosis.
Niemi, N.M., Lanning N.J., Xu, Y., Klomp, J.A., Tait, S.W., Dykema, K.J., Murphy, L.O., Gaither, L.A., Xu, H.E., Furge, K.A., Green, D.R., and J.P. MacKeigan. 2011. Mol Cell Biol. (7):1357-1368.

Last Updated: 10/22/2020 3:51:09 PM

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