Ta-Chiang Liu, M.D., Ph.D.

Associate Professor
Pathology and Immunology
Anatomic & Molecular Pathology

Immunology Program
Developmental, Regenerative and Stem Cell Biology Program
Molecular Microbiology and Microbial Pathogenesis Program

  • 314-747-0343

  • ta-chiang.liu@wustl.edu

  • Understanding how host genetics and environmental factors interact to shape gut metabolism leading to inflammation

Research Abstract:

Our lab explores the following research directions:

-How gene-environment interactions modulates mucosal innate immunity. Using small intestinal Paneth cell function as an index of mucosal innate immunity, we use mouse models, organoid culture, and informatics approach to interrogate the complex of gene-environment interactions.

-How autophagy modulates gut and liver pathophysiology. We are interested in how autophagy pathway controls gut and liver development using genetic and pharmacologic approaches.

-How dietary components modulate gut pathophysiology. We are interested in how dietary fat, sugar, and protein levels modulate response to injury in vivo and stem cell differentiation and survival in vitro.

-Harnessing deep learning to develop algorithms for histopathology. We are developing deep learning algorithms for GI and liver pathology features.

Mentorship and Commitment to Diversity Statement:
I am committed to provide mentorship to the trainees in my laboratory. This includes, and is not limited to, development of scientific ideas, assays, and writing skill. Later in the training I will also provide mentorship in additional career development and networking. In addition, I am committed to diversity and equality in workplace. 

Selected Publications:

Sun L, Marsh J, Matlock MK, Chen L, Gaut JP, Brunt EM, Swamidass SJ, Liu TC. Deep learning quantification of percent steatosis in donor liver biopsy frozen sections. EBiomedicine 2020 (in press).

Liu TC, VanBurkirk K, Ali A, Kelly MP, Holtz LR, Yilmaz OH, Sadiq K, Iqbal N, Amadi B, Syed S, Ahmed T, Moore SR, Ndao IM, Isaacs MH, Pfeifer JD, Atlas H, Tarr PI, Denno DM, Moskaluk CA. A Novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis 2020 Jan 13; 14(1):e0007975.

Kaiko GE, Chen F, Lai CW, Chiang IL, Perrigoue J, Stojmirovic A, Li K, Muegge BD, Jain U, VanDussen KL, Goggins BJ, Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS. PAI-1 augments mucosal damage in colitis. Science Transl Med. 2019; 11(482). pii:eaat0852.

Ingle H, Lee S, Ai T, Orvedahl A, Rodgers R, Zha G, Sullender M, Peterson ST, Locke M, Liu TC, Yokoyama CC, Sharp B, Schultz-Cherry S, Miner JJ, Baldridge MT. Viral complementation of immunodeficiency confers protection against enteric pathogens via IFN-λ. Nat Microbiology. 2019 Jul; 4(7):1120-1128..

Malvin NP, Kern JT, Liu TC, Brody SL, Stappenbeck T. Autophagy proteins are required for club cell structure and function in airways. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1; 317(2):L259-L270. PMID: 31116580.

Wang Y, Chiang IL, Ohara TE, Fujii S, Cheng J, Muegge BD, Ver Heul A, Han ND, Lu Q, Xiong S, Chen F, Lai CW, Janova H, Wu R, Whitehurst CE, VanDussen KL, Liu TC, Gordon JI, Sibley LD, Stappenbeck TC. Long-term culture captures injury-repair cycles of colonic stem cells. Cell 2019 179(5): 1144-1159.PMID: 31708126.

Last Updated: 3/22/2021 1:43:11 PM

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