Jin Zhang, Ph.D.

Assistant Professor
Radiation Oncology
Institute for Informatics

Biomedical Informatics and Data Science Program
Cancer Biology Program
Computational and Systems Biology Program

  • jin.zhang@wustl.edu

  • Developing cutting-edge and integrative data science approaches in translational cancer research

Research Abstract:

My research interests include computational biology and bioinformatics as they apply to cancer genomics and radiation oncology. My doctoral work focused on developing structural variation discovery tools using next-generation sequencing data, including SVseq 1 & 2. I also worked on algorithmic problems in haplotype inference, recombination, rare variants, etc. My postdoctoral work focused on developing algorithms analyzing whole transcriptome sequencing data to discover RNA specific aberrations and their applications in cancers. We designed and implemented the state-of-the-art gene fusion discovery tool, INTEGRATE, leading to his discoveries of novel biomarkers in breast cancer, liver cancer, leukemia, etc. We implemented the first tool in cancer immunology, INTEGRATE-Neo, to predict neo-antigens from tumor specific gene fusion peptides. We discovered a single-gene biomarker, lncRNA PCAT-14, in prostate cancer metastasis, and novel mid-sized small RNAs in acute myeloid leukemia. I am currently working on creating and integrating advanced computational approaches using high-throughput sequencing data and imaging data into the development of novel diagnostic, prognostic, and therapeutic strategies in cancer.

Selected Publications:

Potluri, H.K., Ng, T., Newton, M.A., Zhang, J., Maher, C.A., Nelson, P. S., McNeel, D. G., Antibody Profiling of Prostate Cancer Patients Reveals Differences in Antibody Signatures Among Disease Stages and Following Treatment. Journal for ImmunoTherapy of Cancer. 2020 Dec;8(2):e001510. PMID: 33335027.

Rashmi R., Jayachandran K., Zhang J., Menon V., Muhammad N., Zahner M., Ruiz F., Zhang S., Cho K., Wang Y., Huang X., Huang Y., McCormick M.L., Rogers B.E., Spitz D.R., Patti G.J., Schwarz J.K., Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers. Molecular Cancer Therapeutics. 2020: molcanther.0271.2020. Epub 2020 Oct 21. PMID: 33087507.

Inkman M.J., Jayachandran K., Ellis T.M., Ruiz F., McLellan M.D., Miller C.A., Wu Y., Ojesina A.I., Schwarz J.K., Zhang J., HPV-EM: an accurate HPV detection and genotyping EM algorithm. Scientific Reports. 2020; 10(1): 14340. PMID: 32868873.

Dang H.X., Krasnick B.A., White B.S., Grossman J.G., Strand M.S., Zhang J., Cabanski C.R., Miller C.A., Fulton R.S., Goedegebuure S.P., Fronick C.C., Griffith M., Larson D.E., Goetz B.D., Walker J.R., Hawkins W.G., Strasberg S.M., Linehan D.C., Lim K.H., Lockhart A.C., Mardis E.R., Wilson R.K., Ley T.J., Maher C.A., Fields R.C., The clonal evolution of metastatic colorectal cancer. Science Advances. 2020; 6(24): eaay9691. PMID: 32577507.

Wisdom A.J., Hong C.S., Lin A.J., Xiang Y., Cooper D.E., Zhang J., Xu E.S., Kuo H.C., Mowery Y.M., Carpenter D.J., Kadakia K.T., Himes J.E., Luo L., Ma Y., Williams N., Cardona D.M., Haldar M., Diao Y., Markovina S., Schwarz J.K., and Kirsch D.G., Neutrophils Promote Tumor Resistance to Radiation Therapy, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019; 116 (37): 18584-18589. PMID: 31462499;

Last Updated: 2/13/2021 10:23:24 AM

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