Matthew R. Bersi, Ph.D.

Assistant Professor
Mechanical Engineering & Materials Science
Biomedical Engineering

Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program
Immunology Program

  • 314-935-4159

  • Room 333, Jubel Hall, Danforth Campus

  • mbersi@wustl.edu

  • https://sites.wustl.edu/bersilab/

  • Our research is focused on soft tissue biomechanics and mechanobiology

Research Abstract:

We are located in the Department of Mechanical Engineering & Materials Science at Washington University in St. Louis. Our research is focused on soft tissue biomechanics and mechanobiology.

Using techniques that range from ex vivo tissue testing and mechanical characterization to in vitro cell culture and molecular biology, the ongoing research in the Bersi Lab is generally focused on understanding how alterations in a tissue’s mechanical environment can lead to changes in cellular and molecular activity that promote immune activation, tissue remodeling, and fibrosis. While focused primarily on cardiovascular disease, this multiscale approach has applicability to understanding injury and disease processes in multiple tissues and organ systems.

We aim to better define the intersection between soft tissue biomechanics, molecular biology, and immunology with the ultimate goal of evaluating tissue-specific immunotherapeutic treatment strategies.

Selected Publications:

Hope, J.M., Bersi, M.R., Clinch, A.B., Merryman, W.D., King, M.R. Death of circulating prostate cancer cells exposed to fluid shear stress correlates with increased cell membrane damage and cellular stiffness. Journal of Cell Science. 134(4): jcs251470, 2021.

Snider, J.C., Riley, L.A., Mallory, N.T., Bersi, M.R., Umbarkar, P., Gautam, R., Zhang, Q., Mahadevan-Jansen, A., Hatzopoulos, A.K., Maroteaux, L., Lal, H., Merryman, W.D. Targeting 5-HT2B signalling prevents border zone expansion and improves microstructural remodelling after myocardial infarction. Circulation. 143(13): 1317-1330, 2021.

Bender, J.M., Adams, W.R., Mahadevan-Jansen, A., Merryman, W.D., Bersi, M.R. Radiofrequency ablation alters the microstructural organization of healthy and enzymatically digested porcine mitral valves. Experimental Mechanics. 61(1): 237-251, 2021.

Joll, J.E. 2nd, Clark, C.R., Peters, C.S., Raddatz, M.A., Bersi, M.R., Merryman, W.D. Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse model. PLOS One. 15(11): e0238407, 2020.

Taneja, N., Bersi, M.R., Rasmussen, M.L., Gama, V., Merryman, W.D., Burnette, D.T. Inhibition of focal adhesion kinase increases myofibril viscosity in cardiomyocytes. Cytoskeleton. 77(9): 342-350, 2020.

Last Updated: 4/28/2021 5:25:48 PM

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