Ariella Coler-Reilly

MSTP in PhD Training

Program: Molecular Cell Biology

Current advisor: Roberto Civitelli, MD

Undergraduate university: University of California-Berkeley, 2011

Enrollment year: 2017

Research summary
Unbiased interdisciplinary investigation of age-related genes

Under the guidance of Dr. Roberto Civitelli, I am investigating the role of genes consistently differentially expressed with age. While these genes are the subject of innumerable studies comparing tissues from young and old donors, such studies only describe associations, failing to distinguish drivers of aging from compensatory geroprotective responses and meaningless downstream effects. To address this critical flaw, we developed a workflow to synthesize these data, pinpoint the most consistent expression patterns, and conduct functional experiments to characterize how modulating each pattern affects lifespan and cellular senescence.

Graduate publications
Lee SY, Fontana F, Sugatani T, Portales Castillo I, Leanza G, Coler-Reilly A, Civitelli R. 2024 Connexin43 in mesenchymal lineage cells regulates body adiposity and energy metabolism in mice. JCI Insight, 9(6):e170016. PMCID: PMC11063945

Role of Creation of Plain Language Summaries to Disseminate COVID-19 Research Findings to Patients With Rheumatic Diseases.
Maheswaranathan M, Akpabio A, Tomasella LA, Coler-Reilly A, Richards DP, Howard RA, Ladone N, Sirotich E; COVID-19 Global Rheumatology Alliance, C19-GRA Patient Directed Summaries Team. 2024 Role of Creation of Plain Language Summaries to Disseminate COVID-19 Research Findings to Patients With Rheumatic Diseases. J Rheumatol, 51(5):538-39. PMCID:

Mazi PB, Sahrmann JM, Olsen MA, Coler-Reilly A, Rauseo AM, Pullen M, Zuniga-Moya JC, Powderly WG, Spec A. 2023 The Geographic Distribution of Dimorphic Mycoses in the United States for the Modern Era. Clin Infect Dis, 76(7):1295-1301. PMCID: PMC10319749

Hassan MG, Horenberg AL, Coler-Reilly A, Grayson WL, Scheller E. 2023 Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications. Curr Osteoporos Rep, 21(5):503-18

Elenbaas JS, Jung IH, Coler-Reilly A, Lee PC, Alisio A, Stitziel NO. 2023 The emerging Janus face of SVEP1 in development and disease. Trends Mol Med, 29(11):939-50

Coler-Reilly A, Graef ER, Kim AHJ, Liew JW, Putman MS, Sattui SE, Young KJ, Sparks JA. 2022 Social Media for Research Discourse, Dissemination, and Collaboration in Rheumatology. Rheumatol Immunol Res, 3(4):169-79. PMCID: PMC9984924

Java A, Apicelli AJ, Liszewski MK, Coler-Reilly A, Atkinson JP, Kim AH, Kulkarni HS. 2020 The complement system in COVID-19: friend and foe?. JCI Insight, 5(15):e140711

Rauseo AM, Coler-Reilly A, Larson L, Spec A. 2020 Hope on the Horizon: Novel Fungal Treatments in Development. Open Forum Infect Dis, 7(2):ofaa016