Haewon Shin

Program: Computational and Systems Biology

Current advisor: Kory J. Lavine, MD, PhD

Undergraduate university: Washington University, 2021

Enrollment year: 2021

Research summary
Understanding lncRNA Regulation in Cardiac Inflammation and Heart Failure

Heart failure (HF) remains a major global cause of death and disability, with inflammation driving much of its progression. Despite therapeutic advances, the molecular mechanisms underlying HF are not fully understood. My research focuses on long noncoding RNAs (lncRNAs), which have emerged as key regulators of gene expression and immune signaling. I aim to understand how lncRNAs contribute to cardiac pathology by modulating immune activation and chromatin remodeling, particularly in the context of myocardial infarction and non-ischemic cardiomyopathy. Using single-cell transcriptomic and epigenomic approaches, I investigate how lncRNAs influence inflammatory gene expression and interact with microRNA networks in immune cells and fibroblasts. This work seeks to uncover novel regulatory mechanisms and identify potential RNA-based therapeutic targets for treating HF.

Graduate publications