Irina Shchukina

Program: Immunology

Current advisor: Maxim Artyomov, PhD

Undergraduate university: St. Petersburg State University, 2015

Enrollment year: 2018

Research summary
Age-associated Cd8+ T cells and their role in the immune system aging

Graduate publications
Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, Wang C, Bao X, Finn MB, Hu H, Shchukina I, Kim MW, Yuede CM, Kipnis J, Artyomov MN, Ulrich JD, Holtzman DM. 2023 Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature, 615(7953):668-77. PMCID: PMC10258627

Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, Bando JK, Jaeger N, Czepielewski RS, Swain A, Mogilenko DA, Beatty WL, Bayguinov P, Fitzpatrick JAJ, Schuettpelz LG, Fronick CC, Smirnov I, Kipnis J, Shapiro VS, Wu GF, Gilfillan S, Cella M, Artyomov MN, Kleinstein SH, Colonna M. 2021 Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science, 373(6553):eabf9277. PMCID: PMC8448524

Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. 2020 Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nat Metab, 2(1):50-61. PMCID:

Esaulova E, Cantoni C, Shchukina I, Zaitsev K, Bucelli RC, Wu GF, Artyomov MN, Cross AH, Edelson BT. 2020 Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation. Neurol Neuroimmunol Neuroinflamm, 7(4):e732. PMCID: PMC7217663

Mogilenko DA, Shpynov O, Andhey PS, Arthur L, Swain A, Esaulova E, Brioschi S, Shchukina I, Kerndl M, Bambouskova M, Yao Z, Laha A, Zaitsev K, Burdess S, Gillfilan S, Stewart SA, Colonna M, Artyomov MN. 2020 Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK + CD8 + T Cells as Conserved Hallmark of Inflammaging. Immunity, 54(1):99-115.e12. PMCID: