Current advisor: Erik S. Musiek, MD, PhD
Undergraduate university: University of Delaware, 2018
Enrollment year: 2019
Studying how the astrocyte circadian clock may regulate neutrophil infiltration into the CNS during different neurodegenerative diseases.
We propose a unique mechanism by which circadian regulation of CXCL5 in astrocytes allows for tight temporal and spatial control over BBB breakdown and leukocyte extravasation. CXCL5 is a potent chemokine that both induces BBB breakdown and neutrophil chemotaxis – two immune responses critical during neurodegeneration.