Lingzhen Kong

Program: Molecular Cell Biology

Current advisor: Zhongsheng You, PhD

Undergraduate university: Cornell University, 2017

Enrollment year: 2017

Research summary
Mechanistic dissection of a Ca2+-mediated genome protection pathway during DNA replication

Graduate publications
Li S, Kong L, Meng Y, Cheng C, Lemacon DS, Yang Z, Tan K, Cheruiyot A, Lu Z, You Z. 2023 Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks. Mol Cell, 83(4):556-573.e7. PMCID: PMC9974760

Kong T, Yu L, Laranjeira ABA, Fisher DAC, He F, Cox MJ, Oh ST. 2023 Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms. Am J Hematol, 98(7):1029-1042. PMCID:

Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress.
Yang Z, Lemacon DS, Li S, Cheruiyot A, Kong L, Tan K, Cheng C, Turkay E, He D, You Z.. 2022 Context-dependent pro- and anti-resection roles of ZKSCAN3 in the regulation of fork processing during replication stress. J Biol Chem, 298(8):102215. PMCID: PMC9352557

Goodman JV, Yamada T, Yang Y, Kong L, Wu DY, Zhao G, Gabel HW, Bonni A. 2020 The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain. Nat Commun, 11(1):3419. PMCID: PMC7347877

Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z. 2019 Ca 2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks From Aberrant Resection. Mol Cell, 74(6):1123-1137.e6. PMCID: PMC6588484