Nicolas Ledru

Program: Molecular Genetics and Genomics

Current advisor: Benjamin D. Humphreys, MD, PhD

Undergraduate university: Brown University, 2016

Enrollment year: 2017

Research summary
Gene regulation in proximal tubule sub-types in chronic kidney disease

In the Humphreys lab, we use single cell sequencing techniques to study a proximal tubule subpopulation that appears to drive progressive damage and kidney disease. This population has been studied following acute kidney injury (AKI) and is associated with failure to recover and subsequent transition to chronic kidney disease (CKD). I am exploring this subpopulation’s presence and activity in kidneys that have not experienced AKI and whether it can drive CKD progression in other non-acute modes of kidney injury

Graduate publications
Muto Y, Wilson PC, Ledru N, Wu H, Dimke H, Waikar SS, Humphreys BD. 2021 Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat Commun, 12(1):2190.

Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD. 2019 The single-cell transcriptomic landscape of early human diabetic nephropathy. Proc Natl Acad Sci USA, 116(39):19619-19625.