Peter Lambert

Program: Neurosciences

Current advisor: Steven J. Mennerick, PhD

Undergraduate university: Rice University, 2016

Enrollment year: 2016

Research summary
Modulation of GABAA receptor physiology with neuroactive steroid compounds

Working in Dr. Steven Mennerick’s lab in the department of psychiatry, I study the GABA neurotransmitter system and its role in the mechanisms of rapid acting antidepressants. We combine both in vitro and in vivo electrophysiological methods to study neurosteroids and their modulation of GABA receptors. We hope to further characterize the ways that neurosteroids regulate and modify circuit and network activity in the brain to better understand how they may produce antidepressant responses. We hope that this will lead to the further development of neuroactive steroid treatments for psychiatric illness.

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Graduate publications
Lu X, Lambert P, Benz A, Zorumski CF, Mennerick SJ. 2023 Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons. eNeuro, 10(3):ENEURO.0392-22.2023. PMCID: PMC10012327

Lambert PM, Lu X, Zorumski CF, Mennerick S. 2022 Physiological markers of rapid antidepressant effects of allopregnanolone. J Neuroendocrinol, 34(2):e13023

Lambert PM, Ni R, Benz A, Rensing NR, Wong M, Zorumski CF, Mennerick S. 2022 Non-sedative cortical EEG signatures of allopregnanolone and functional comparators. Neuropsychopharmacology, (epub ahead of print):. PMCID:

Ziolkowski L, Mordukhovich I, Chen DM, Chisari M, Shu HJ, Lambert PM, Qian M, Zorumski CF, Covey DF, Mennerick S. 2021 A neuroactive steroid with a therapeutically interesting constellation of actions at GABA A and NMDA receptors. Neuropharmacology, 183():108358. PMCID: PMC7736525

Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, Mennerick S. 2019 Mild chronic perturbation of inhibition severely alters hippocampal function. Sci Rep, 9(1):16431. PMCID: PMC6848214