Molecular Genetics and Genomics

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Genetic analysis of neural and muscular development in the Drosophila embryo

Key words
development, neurobiology, cell signaling

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics

Research summary
Investigating how plant cells determine which fragments of DNA should be expressed (like genes), and which should be targeted for repression and not allowed to express

Key words
transposable element, epigenetics, DNA methylation, chromatin, transgene silencing

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.

Key words
Epigenetics, chromatin, cancer, mouse models, lymphoma, melanoma, EZH2, PRC2, H3K27me3

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.

Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy

Key words
aging, cancer, microenvironment, RNAi, senescence, telomere

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We use multiomic approaches to discover mechanisms underlying cardiovascular disease and leverage these insights to identify new drug targets.

Key words
Human genetics; cardiovascular disease

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Biochemistry Biophysics and Structural Biology

Research summary
Computational biology, bioinformatics, protein-DNA interactions, gene regulation

Key words
computational biology, genome analysis, gene expression, mathematical modeling

Program affiliation
Ecology and Evolutionary Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences

Research summary
We work on social interactions and mutualism using a microbial system so we can study cheating, conflict and cooperation at experimental and genomic levels, within and between species, in particular in social amoebae and their farmed bacteria

Key words
social evolution; multicellularity; mutualism; symbiosis; experimental evolution; disease; social amoebae; Dictyostelium; science education; birds

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals