Xuan Qu

Program: Computational and Systems Biology

Current advisor: Ting Wang, PhD

Undergraduate university: Bowdoin College, 2017

Enrollment year: 2017

Research summary
Regulation of transposable elements in cancer

My current project aim to understand the regulation of transposable elements in cancer under p53. Previous studies have illustrated the correlation between the presence of p53 mutation and increased expression of transposable elements. However, there is a lack of systematic characterization for such phenomenon across all repeat elements and a lack of detailed understanding of the specific mechanism underlying such correlation. My project hopes to charactize this correlation in a genomic and epigenomic perspective. I also hope to unveil some elements involved in this regulatory pathway.

Graduate publications
DeSouza PA, Qu X, Chen H, Patel B, Maher CA, Kim AH. 2021 Long, Noncoding RNA Dysregulation in Glioblastoma. Cancers (Basel), 13(7):1604.

Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao DD, Hafez D, Yang W, Taiwo R, Paturu M, Salehi A, Gujar AD, Dunn GP, Mosammaparast N, Petti AA, Yano H, Kim AH. 2021 Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Nat Commun, 12(1):6321. PMCID: PMC8566473