Biomedical Informatics and Data Science

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Biomedical Informatics and Data Science

Research summary
Focused on the analysis of high dimensional omics (epigenetics and microbiome) data, subgroup identification, medical cost data, and joint models of multi-outcome data

Key words
Biostatistics, data science, machine learning, precision medicine, omics study, biomedical data mining

Program affiliation
Biomedical Informatics and Data Science

Research summary
Dr. Jose Marcio Luna’s research focuses on the development of translational tools for prediction and diagnosis of cancer from a multi-omics perspective in the era of precision medicine.

Key words
Machine Learning, Data Sciences, Data Integration, Optimization Theory and Computational Medical Imaging

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
The Mansfeld Lab uses various non‑model species and a hypothesis driven, systems approach to examine how circadian rhythm, development, and tissue type impact plant defense.

Key words
Plant Pathology, Genomics, Bioinformatics, Disease Resistance

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Cancer Biology

Research summary
Artificial intelligence and informatics to support open science and translational research

Key words
informatics imaging AI open science

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Development of liquid biopsy approaches for brain tumors

Key words
liquid biopsy, cfDNA, genetics, epigenetics

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
My lab focuses on developing imaging methods to characterize brain fluid compartments, tissue microstructure and neurofluid dynamics in health and disease. In addition, by perturbing brain fluid compartments, we aim to develop novel therapeutic and diagnostic approaches.

Key words
Neurofluid Imaging, Translational Neuroimaging, Preclinical MRI, CSF, Computational Neuroanatomy, Focused Ultrasound, Neurodevelopment, Neurodegenerative Disorders, Drug Delivery

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology

Research summary

Key words
Nutrition, Cancer, Epidemiology, Risk prediction, Population health

Program affiliation
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics

Key words
metabolism, metabolomics, mass spectrometry, bioinformatics, imaging, cancer, tumor microenvironment, isotope tracing

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Translational Bioinformatics, Clinical Research Informatics

Key words
Biomedical Informatics, Data Science, Data Analytics, Clinical Research, Translational Research