Biomedical Informatics and Data Science

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology

Research summary
Development of novel statistical methods for precision medicine

Key words
Biostatistics; Image analysis; Dynamic risk prediction; Multistate models

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Molecular Cell Biology

Research summary
We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying human disease

Key words
Functional genomics, bioinformatics, human genetics, data science, rare diseases, structural variation

Program affiliation
Biomedical Informatics and Data Science

Research summary
Integrating cognitive, behavioral, and computational informatics techniques for developing health information technology solutions in the areas of clinical decision support, clinical reasoning, and clinical workflow

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Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary

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Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
My lab uses transcranial focused ultrasound to provide noninvasive therapies of disorders of brain function.

Key words
neuromodulation, neural engineering

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Cortical synaptic, neural, and circuit mechanisms underlying auditory (hearing) deficits in neurological and neurodevelopmental disorders, including noise-induced hearing loss, hyperacusis, and autism. We employ a multidisciplinary approach including, in vivo two-photon microscopy in awake mice, auditory behavioral assays, ex vivo brain-slice imaging and electrophysiology, chemogenetic and optogenetic circuit manipulation, inducible conditional knockout models, and pharmacological interventions.

Key words
Auditory Neuroscience, Autism, Cortical Neural and Circuit Mechanisms, Auditory Driven Behavior, Two-photon Microscopy, Optogenetics/Chemogenetics

Program affiliation
Biomedical Informatics and Data Science
Neurosciences
Computational and Systems Biology

Research summary

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Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
My research is in clinical research informatics, but I also have strong interest in other areas of clinical informatics, including usability of clinical and consumer-facing systems and mobile health

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Program affiliation
Biomedical Informatics and Data Science

Research summary

Key words

Program affiliation
Biomedical Informatics and Data Science
Neurosciences

Research summary
The Lee Laboratory develops computational approaches to advance precision medicine through retinal imaging, artificial intelligence, and multimodal biomedical data. Our research integrates ophthalmic imaging, clinical phenotypes, wearable sensors, electronic health records, and multi-omics to discover noninvasive biomarkers of systemic diseases, including diabetes, Alzheimer's disease, and cardiovascular disease. Through large-scale collaborative studies such as Eye ACT, AI-READI, and the Framingham Heart Study Eye Project, we build open, AI-ready resources that accelerate scientific discovery and improve patient care.

Key words
Big Data, AI, Ophthalmology, Clinical Epidemiology, Alzheimer's, Oculomics