Molecular Genetics and Genomics
Grant Challen, PhD
Professor
- Email: grantchallen@wustl.edu
Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells
Key words
Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications
Chun-Kan Chen, PhD
Assistant Professor
- Email: chun-kan@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
The Chen lab utilizes multi-omic and high-throughput screening approaches to investigate the regulation and function of circRNA and uncover the molecular mechanisms of circRNA-mediated disease.
Key words
Circular RNA, Oxidative Stress, RNA Translation, Cancer Vaccine
David Chen, MD,PhD
Assistant Professor
- Email: davidchen@wustl.edu
Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Defining drivers of premalignant states in skin
Key words
epigenetics, aging, cancer, premalignancy, dermatology, melanoma, nevi, squamous cell carcinoma
Haobin Chen, MD, PhD
Assistant Professor
- Email: c.haobin@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Identifying new therapeutic targets of small cell lung cancer
Key words
Lung cancer, DNA damage repair, immunology, drug resistance, genetic screening, translational research, drug development, targeted therapy, precision therapy
Shiming Chen, PhD
Dr. Bernard and Janet R. Becker Distinguished Professor
- Email: chenshiming@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences
Research summary
Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas
Key words
Gene expression regulation, transcription factors, epigenetic regulators, photoreceptor development and degeneration, mouse models, gene therapy
Yao Chen, PhD
Assistant Professor
- Email: yaochen@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals
Key words
neuromodulator, sleep, dynamics, sensors, actuators, signaling, G protein coupled receptors, imaging, microscopy, learning, plasticity, engineering
Ying Chen, MD, PhD
Assistant Professor
- Email: ychen32@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Research summary
Understanding the molecular mechanisms of primary nephrotic syndrome (NS)
Key words
Milan Chheda, MD
Associate Professor
- Email: mchheda@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
Key words
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
Roberto Civitelli, MD
Professor
- Email: civitellir@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Research summary
Connexins, cadherins in bone cell interactions with cancer and energy metabolism
Key words
bone biology, cell adhesion, signal transduction, gap junctions, cadherin
Brian Clark, PhD
Assistant Professor
- Email: brian.s.clark@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Research summary
Analysis of the temporally regulated program of retinal cell type specification.
Key words