Molecular Genetics and Genomics

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
How genetic variation and environmental experience contribute to individual differences in brain function, behavior, and psychopathology

Key words

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
Microbial metabolisms and their influence on biogeochemical cycling

Key words

Program affiliation
Computational and Systems Biology
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Computational genomics, human genetics, systems biology, transcriptional regulatory networks

Key words
computational biology, systems biology, regulatory circuits, computational genomics, multi-omics integration, human genetics

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Biology of DNA replication and damage response in yeast and human

Key words
Cell cycle, DNA damage response, DNA replication, Checkpoints, Mutagenesis, DNA repair, yeast

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
We study disease-relevant cell and organ signaling pathways in inflammatory bowel disease using molecular and cell biology, multi-omics technologies, genetic murine models, and patient samples.

Key words
inflammatory bowel disease, mucosal immunity, innate lymphoid cells, human intestinal organoids, regenerative medicine, biomarker discovery, cellular stress response, perianal fistulizing Crohn's disease, eosinophilic esophagitis, colon cancer

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the role of endogenous opioids in affective neuroscience and metabolic homeostasis

Key words
reward, valence, opioid, motivation, metabolism, diabetes

Program affiliation
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Developmental Regenerative and Stem Cell Biology

Research summary
Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena, control of intercellular patterning

Key words
cellular patterning, cell biology, basal bodies and cilia, chromatin structure, development, DNA, genome rearrangements, RNA interference,

Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells

Key words
Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary

Key words

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
The Chen lab utilizes multi-omic and high-throughput screening approaches to investigate the regulation and function of circRNA and uncover the molecular mechanisms of circRNA-mediated disease.

Key words
Circular RNA, Oxidative Stress, RNA Translation, Cancer Vaccine