Faculty

Program affiliation
General

Research summary
My research centers on defining how the dynamic conformational landscape of drug targets governs ligand binding, selectivity, and downstream signaling. Using integrated approaches—including molecular dynamics simulations, pharmacophore modeling, and virtual screening—I identify and characterize novel modulators for several targts. These studies uncover previously unrecognized binding pockets, reveal mechanisms of ligand-induced activation or inhibition

Key words

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

Program affiliation
Molecular Cell Biology

Research summary
We aim to identify cellular and molecular mechanisms in the novel and rapidly expanding field of interorgan crosstalk in health and disease.

Key words

Program affiliation
Neurosciences

Research summary
Clinical neuroscience of diabetes and related diseases

Key words
neuroimaging, diabetes, hyperglycemia, hypoglycemia, Wolfram Syndrome, Parkinson disease, cognition, mood

Program affiliation
Cancer Biology
Immunology

Research summary

Key words

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science

Research summary
Molecular, cellular and circuit analysis of circadian rhythms in mammals

Key words
neurobiology, behavior, imaging, circadian rhythm, glia, brain cancer, potassium channels, neuropeptides, astrocytes, glioblastoma, cancer, developmental biology, computational modeling

Program affiliation
General

Research summary
Electron microscopy of cells and molecules

Key words
cell membrane, cytoskeleton, endocytosis, electron microscopy, extracellular matrix

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Understanding the learning mechanisms of the brain from theoretical and computational perspectives

Key words
Computational neuroscience, Synaptic plasticity, Olfaction, Deep learning