Faculty

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
My lab works on the host immune response to Mycobacterium tuberculosis. We use mouse models that mimic key aspects of human disease to gain a mechanistic understanding of the host response allowing for the identification of novel targets for host-directed therapies.

Key words
Mycobacterium tuberculosis, innate immunology, macrophages, neutrophils, dendritic cells

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Mechanisms of neurodegeneration in Parkinson`s disease and related disorders

Key words
lipid metabolism, mouse models, neurodegeneration, pathogenesis, phospholipase A2, Parkinson disease

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Quantitative cardiovascular physiology, mathematical modeling of systems physiology, imaging

Key words
biophysics, cardiology, cardiovascular physiology, echocardiography, imaging, mathematical modeling

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Our laboratory focuses on the fundamental issues of DNA repair and how they relate to cancer initiation, progression, and therapy responses.

Key words
DNA repair, DNA replication

Program affiliation
General

Research summary
Gene regulation and biogenesis of extracellular components in bacteria

Key words
bacteria, gene expression, protein structure, plant biosensors, cytochromes

Program affiliation
Neurosciences

Research summary
The study of basal ganglia circuits and how their function changes in disease states such as obesity, addiction, and anxiety disorders

Key words

Program affiliation
Immunology
Molecular Cell Biology

Research summary

Key words

Program affiliation
Neurosciences

Research summary
circadian system influence on the limbic system during Alzheimer's disease pathogenesis and aging

Key words
Alzheimer's Disease, Circadian System, Hippocampal Physiology, Neurodegeneration

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Neurosciences

Research summary
Transcriptional and epigenetic regulation of neural development and its dysregulation to cause neurodevelopmental disorders

Key words
human pluripotent stem cell, autism, neuron, neurodevelopmental disorders, cerebral organoid, epigenetic regulation, transcriptional regulation, neurobiology, embryonic stem cell, neural stem cell, transcription, gene regulatory network, chromatin, embryo

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
My lab uses transcranial focused ultrasound to provide noninvasive therapies of disorders of brain function.

Key words
neuromodulation, neural engineering