Biochemistry Biophysics and Structural Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Plant and Microbial Biosciences

Research summary
Interfaces and adhesions in physiology and nature

Key words
mechanics, physics, interfaces, adhesion, mechanobiology, strain mapping, viscoelasticity

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Biochemistry of malaria

Key words
biochemistry, metabolism, parasitology, malaria, protease, heme, aspartic

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Computational mass spectrometry and proteomics

Key words
Mass Spectrometry, Proteomics, Bioinformatics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Relationship of structure to function in allosteric control mechanisms

Key words
protein structure, protein function, allosteric regulation, enzymology, biochemistry

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
My long-term research interest focuses on the generation and transduction of mechanical forces in cardiovascular disease. In particular, my lab utilizes an array of biophysical, biochemical, cell biological, and engineering techniques to decipher how mutations associated with familial cardiomyopathies drive disease pathogenesis at the molecular, cellular, and tissue levels. My lab is also working to develop precision medicine approaches for pediatric and adult heart failure.

Key words
single molecule, biophysics, heart disease, myosin, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding tumor-microenvironment interactions and metastasis with a focus in ovarian cancer models

Key words
tumor microenvironment, microfluidics, metastasis, cancer, signal transduction

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Development and application of mass spectrometry in biophysics, biochemistry, and medicine

Key words
amyloid beta biophysics, biochemistry, biophysics, mass spectrometry, protein-protein interaction, protein structure,

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
We study RNA folding and RNA binding to proteins

Key words
RNA, NMR, RNA:protein interactions, fluorescence, thermodynamics