Biochemistry Biophysics and Structural Biology
Doug Frantz, PhD
Professor
- Email: dougf@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Small molecule drug discovery inspired research across multiple therapeutic areas including chronic pain, oncology, and neurodegeneration.
Key words
drug discovery, medicinal chemistry, chemical biology, synthetic methods
Daved Fremont, PhD
Professor
- Email: fremont@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Mechanisms of host immunity and viral evasion
Key words
immunology, virology, structural biology, viral immune evasion, cytokine receptors, signaling, protein trafficking
James Friend, PhD
Stephen F. & Camilla T. Brauer Distinguished Professor and Department Chair of Mechanical Engineering & Materials Science
- Email: jamesfriend@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Research summary
Key words
Ziao Fu, PhD
Assistant Professor
- Email: ziao@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Immunology
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis
Research summary
Dr. Fu’s research focuses on the structural and functional analysis of SPFH family proteins. Using cryo-electron microscopy and cryo-electron tomography, the Fu Lab studies membrane proteins in their native environments to explore their role in cellular signaling and disease
Key words
cryoem structure Ion channel membrane protein cryoet
Eric Galburt, PhD
Professor
- Email: egalburt@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Biophysical studies of transcription initiation in Eukaryotes and Mycobacterial tuberculosis
Key words
biophysics, kinetics, optical and magnetic trapping, transcription, fluorescence
Roberto Galletto, PhD
Associate Professor
- Email: galletto@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Mechanistic studies of DNA motor proteins; single Molecule Biochemistry
Key words
Benjamin Garcia, PhD
Professor and Head of the Department of Biochemistry and Molecular Biophysics
- Email: bagarcia@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Quantitative proteomics for understanding protein and proteome modifications
Key words
Guy Genin, PhD
Harold & Kathleen Faught Professor
- Email: genin@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Plant and Microbial Biosciences
Research summary
Interfaces and adhesions in physiology and nature
Key words
mechanics, physics, interfaces, adhesion, mechanobiology, strain mapping, viscoelasticity
Aliereza Ghanbarpour, PhD
Assistant Professor
- Email: alirezag@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology
Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.
Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria
Daniel Goldberg, MD, PhD
Professor
- Email: dgoldberg@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Research summary
Biochemistry of malaria
Key words
biochemistry, metabolism, parasitology, malaria, protease, heme, aspartic