Biochemistry Biophysics and Structural Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
The Greenberg lab seeks to understand the molecular and cellular biophysics of heart disease, with the goal of engineering disease models and precision therapeutics

Key words
heart disease, single molecule, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Development and application of mass spectrometry in biophysics, biochemistry, and medicine

Key words
amyloid beta biophysics, biochemistry, biophysics, mass spectrometry, protein-protein interaction, protein structure,

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
The molecular mechanisms through which biologic membranes participate in cellular activation processes

Key words
phospholipase A2, diabetes, obesity, receptor, myocardial ischemia, lipid metabolism

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
We study RNA folding and RNA binding to proteins

Key words
RNA, NMR, RNA:protein interactions, fluorescence, thermodynamics

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging

Key words
Chemical Biology, Molecular Recognition, Biomolecular Assembly, Nucleic Acids, Biosensors, Cellular Imaging, RNA Editing, Biomaterials

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches

Key words
Disordered proteins, IDPs, IDRs, phase transitions, emergence, deep learning, AI, bird-themed software packages

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)