Biochemistry Biophysics and Structural Biology

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches

Key words
Disordered proteins, IDPs, IDRs, phase transitions, emergence, deep learning, AI, bird-themed software packages

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Our research program integrates protein engineering and systems neuroscience to address previously inaccessible questions about brain function, particularly in the area of social behavior.

Key words
Social Behavior, Protein engineering, Optics, Neural dynamics, Genetically encoded optical tools

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences

Research summary
Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation

Key words
cancer, metabolism, imaging, sex differences, body composition

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences

Research summary
Protein folding and misfolding, and the engineering and application of protein disaggregases to reverse misfolding

Key words
protein folding and misfolding; intrinsically disordered proteins, phase separation, and neurodegenerative disease; protein chaperones; protein engineering; amyloid; yeast models of protein misfolding

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease

Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
we study the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions including cell migration, intracellular trafficking and cytokinesis.

Key words
actin cytoskeleton, microtubule, single molecule, live cell imaging, protein transport, Golgi, confocal microscopy

Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology

Research summary
Exploring regulatory networks in metabolism - structural biology and biochemistry of plants and microbes

Key words
biochemistry, enzymology, plant biology, protein engineering, protein structure, structural biology