Computational and Systems Biology

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Ecology and Evolutionary Biology
Biochemistry Biophysics and Structural Biology

Research summary
(1) Dynamics, ecology, and evolution of antibiotic resistance, (2) Engineering enhanced probiotics to treat GI disorders, (3) Engineering microbial biofuel catalysts

Key words
anibiotic resistance, synthetic biology, bioenergy, human microbiome, metagenomics, microbial ecology and biodiversity

Program affiliation
Ecology and Evolutionary Biology
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
We integrate metabolic, movement, and community ecology to address core and applied ecological and evolutionary questions. Spanning diverse species and habitats, our research links individual physiology to global biodiversity patterns using theory, data, experiments, and field studies. We aim to understand ecological systems, including human impacts, to inform effective management and policy.

Key words
metabolism, movement ecology, community ecology, behavior, species interactions, human-nature interactions, biogeography, global change, computer vision, eco-informatics, complex systems, biodiversity, great river systems, ecological management

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer Proteogenomics and Cancer Models

Key words

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology
Human and Statistical Genetics

Research summary
Human Psychiatric Genetics, Mouse Models, Cell Type Specific Gene Expression Profiling, Translation, Astrocytes.

Key words
autism, gene expression profiling, genetics, genomics, mouse models, neurobiology, astrocytes, translation regulation

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
We develop new computational and experimental approaches to understand the roles of DNA methylation and hydroxymethylation in neurodevelopment and cancer

Key words
bioinformatics, cancer, cancer genomics, epigenetics, epigenomics, neurodevelopment, transcriptional regulation

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology

Research summary
Medicinal chemistry with a broad goal of drug design and organic synthesis

Key words

Program affiliation
Computational and Systems Biology
Immunology
Cancer Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
My research interests lie in integrating and applying novel computational biology techniques with mechanistic experimental immunology to understand drivers of response and resistance to NK cell therapies for cancer

Key words
natural killer cells, computational biology, single-cell sequencing, immunotherapy, nk cells

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Computational mass spectrometry and proteomics

Key words
Mass Spectrometry, Proteomics, Bioinformatics