Computational and Systems Biology

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology

Research summary
Novel genetic, microbial, and lifestyle risk factors for lung and gastrointestinal cancers leveraging large-scale clinical and population-based cohorts with deep genomic and phenotypic data

Key words
Systems and translational cancer epidemiology, microbiome, inflammation and immune-metabolic networks

Program affiliation
Neurosciences
Ecology and Evolutionary Biology
Computational and Systems Biology

Research summary
Sensory and Evolutionary Neuroscience

Key words
neural circuits, neurophysiology, sensory systems, behavior, evolution, mathematical modeling

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the role of endogenous opioids in affective neuroscience and metabolic homeostasis

Key words
reward, valence, opioid, motivation, metabolism, diabetes

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Exploring neuromorphic architectures using silicon and biological neurons; Novel self-powered neural recording systems

Key words

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary

Key words

Program affiliation
Neurosciences
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
We develop innovative computational analytical methodologies for studying brain health and neuropsychiatric and neurological disorders such as schizophrenia and Alzheimer’s. The lab employs AI and multimodal neuroimaging — including PET, MRI/fMRI, and EEG — as well as behavioral, clinical and genetic approaches for designing predictive models, identifying disease heterogeneity dimensions and facilitating precision medicine

Key words
Neuroimaging, neurophysics, neuroinformatics, computational neuroscience, clinical research, artificial intelligence, machine learning, deep learning, big data, neuropsychiatric and neurological disorders, neuroimaging-genetics, neuroimaging-behavior

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary
Health and economic burden of obesity and surgical treatments of obesity, transplant outcomes, multiple myeloma prevention and control, and health disparities.

Key words

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals

Key words
neuromodulator, sleep, dynamics, sensors, actuators, signaling, G protein coupled receptors, imaging, microscopy, learning, plasticity, engineering

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Genomic analyses of regulatory networks, Non-coding disease variants

Key words
Genomics, Genetic Variation, High-Throughput Technologies, Single-Cell Regulatory Genomics, Computational Biology

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Disease mechanisms and treatments for inherited childhood neurodegeneration

Key words
Batten Disease, Neuronal Ceroid Lipofuscinosis, NCL, Lysosomal Storage Disease, pathogenesis, pre-clinical therapies, enzyme replacement, gene therapy