Computational and Systems Biology

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Genetic variation in the variable response to pharmacologic treatment (i.e. Pharmacogenomics) of cardiovascular disease; specifically individuals with both diabetes mellitus and coronary artery disease.

Key words
cardiovascular disease, diabetes melitus, genotype, genetic variation

Program affiliation
Human and Statistical Genetics
Neurosciences
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
The goal of my lab is to understand the biology of neurodegeneration by using high-dimensional omic data and functional genomic approaches.

Key words
Neurodegeneration, Alzheimer, genetics, genomics, proteomics, system biology, molecular phenotyping, functional genomics

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
(1) Dynamics, ecology, and evolution of antibiotic resistance, (2) Engineering enhanced probiotics to treat GI disorders, (3) Engineering microbial biofuel catalysts

Key words
anibiotic resistance, synthetic biology, bioenergy, human microbiome, metagenomics, microbial ecology and biodiversity

Program affiliation
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
We integrate metabolic, movement, and community ecology to address core and applied ecological and evolutionary questions. Spanning diverse species and habitats, our research links individual physiology to global biodiversity patterns using theory, data, experiments, and field studies. We aim to understand ecological systems, including human impacts, to inform effective management and policy.

Key words
metabolism, movement ecology, community ecology, behavior, species interactions, human-nature interactions, biogeography, global change, computer vision, eco-informatics, complex systems, biodiversity, great river systems, ecological management

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer Proteogenomics and Cancer Models

Key words

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Our research program is dedicated to advance the understanding of healthy brain aging, neuropsychiatric, and neurodegenerative disorders using multi-omic approaches.

Key words
aging, major depression, proteomics, multi-omics, precision medicine, clinical trials, cellular senescence

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Cells are not just bags of molecules - they organize their biochemistry in space, often using dynamic compartments called biomolecular condensates. Our lab is asking fundamental questions about the role of condensates in biology, such as: how do condensate environments influence RNA recognition and metabolism? How do they alter the activity of therapeutics? And how do they contribute to oncogenic cell states? We do this using interdisciplinary approaches spanning chemical biology, quantitative cell microscopy, in vitro biophysics, and machine learning. We hope to ultimately uncover how subcellular organization shapes cellular function and how these principles can be harnessed therapeutically.

Key words
condensates, RNA, chemical biology, therapeutics, microscopy, cancer