Computational and Systems Biology

Program affiliation
Computational and Systems Biology
Immunology
Cancer Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
My research interests lie in integrating and applying novel computational biology techniques with mechanistic experimental immunology to understand drivers of response and resistance to NK cell therapies for cancer

Key words
natural killer cells, computational biology, single-cell sequencing, immunotherapy, nk cells

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Cancer Biology

Research summary
We study host-microbe and microbe-microbe interactions in the female reproductive and urinary tracts, with a focus on the vaginal microbiome, UTI, and adverse pregnancy outcomess

Key words
bacteria, bacterial pathogenesis, urinary tract infection, vaginal microbiome, women's health, host-pathogen interactions, mucosal immunology, epithelium

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Computational mass spectrometry and proteomics

Key words
Mass Spectrometry, Proteomics, Bioinformatics

Program affiliation
Immunology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Our research is dedicated to investigating the immunobiological pathways that underlie such pregnancy complications, with a special emphasis on preterm birth.

Key words
Immunology of Pregnancy, Maternal-fetal Immunology, In utero Inflammation, Preterm Birth

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Understanding the computational principles that underly brain development, using a combination of experimental and theoretical approaches

Key words
NeuroAI, Zebrafish, Computational Neuroscience, Autism, Sleep, Machine Learning

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity

Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology

Research summary

Key words

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research