Computational and Systems Biology

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary

Key words

Program affiliation
Immunology
Computational and Systems Biology

Research summary
Studying effects of dysregulated nutrients in the tumor microenvironment on anti-tumor immunity.

Key words
immunometabolism, tumor immunology, polyamine transport

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Understanding the learning mechanisms of the brain from theoretical and computational perspectives

Key words
Computational Neuroscience, NeuroAI, Synaptic Plasticity, Olfaction, Continual Learning, Deep Learning

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches

Key words
Disordered proteins, IDPs, IDRs, phase transitions, emergence, deep learning, AI, bird-themed software packages

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Sensory processing and plasticity (olfaction), large-population calcium imaging, computation, social communication

Key words
calcium imaging, physiology, mathematical modeling, behavior, neurobiology, smell, olfaction, pheromones, neuroendocrine, circuits

Program affiliation
Neurosciences
Molecular Cell Biology
Computational and Systems Biology

Research summary
Our lab deciphers how fruit flies learn, memorize, and make decisions using state-of-the-art optical imaging techniques

Key words
Voltage imaging, computational modeling, learning system, memory processing, Drosophila melanogaster

Program affiliation
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Define cell hierarchies in kidney injury and repair and thereby identify the critical cell types in kidney repair and fibrosis

Key words
Stem cells, regenerative medicine, scRNA-seq, scATAC-seq, spatial transcriptomics, fibrosis, gene editing, iPS cells

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Molecular Cell Biology

Research summary
We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying human disease

Key words
Functional genomics, bioinformatics, human genetics, data science, rare diseases, structural variation