Computational and Systems Biology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Define cell hierarchies in kidney injury and repair and thereby identify the critical cell types in kidney repair and fibrosis

Key words
Stem cells, regenerative medicine, scRNA-seq, scATAC-seq, spatial transcriptomics, fibrosis, gene editing, iPS cells

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Molecular Cell Biology

Research summary
We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying human disease

Key words
Functional genomics, bioinformatics, human genetics, data science, rare diseases, structural variation

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary

Key words
tumor growth, metastasis, signaling mechanisms, immunology, cancer, B cells, Tregs

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Microbial community-immune interactions in airway diseases and urogenital tract

Key words
microbiota; microbiome; mucosal immunity; asthma; allergy; atopy; urinary tract infection; pathogen colonization; metabolomics;

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Neurobiology of cognition, decision-making and applications to biological psychiatry. Brain-body interactions

Key words

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences
Cancer Biology

Research summary
Genetic and epigenetic changes that drive malignant behavior in brain tumors

Key words
brain tumors, glioblastoma, meningioma, neural stem cells

Program affiliation
Immunology
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
understand the biology of different human dendritic cells and other myeloid cells as a key for manipulating immune responses in various disease conditions

Key words
Human Immunology, Dendritic Cells, Tumor Immunology, immune dysfunctions, Vaccines

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary

Key words

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
My lab works on the host immune response to Mycobacterium tuberculosis. We use mouse models that mimic key aspects of human disease to gain a mechanistic understanding of the host response allowing for the identification of novel targets for host-directed therapies.

Key words
Mycobacterium tuberculosis, innate immunology, macrophages, neutrophils, dendritic cells

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Cortical synaptic, neural, and circuit mechanisms underlying auditory (hearing) deficits in neurological and neurodevelopmental disorders, including noise-induced hearing loss, hyperacusis, and autism. We employ a multidisciplinary approach including, in vivo two-photon microscopy in awake mice, auditory behavioral assays, ex vivo brain-slice imaging and electrophysiology, chemogenetic and optogenetic circuit manipulation, inducible conditional knockout models, and pharmacological interventions.

Key words
Auditory Neuroscience, Autism, Cortical Neural and Circuit Mechanisms, Auditory Driven Behavior, Two-photon Microscopy, Optogenetics/Chemogenetics