Human and Statistical Genetics

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
We develop new computational and experimental approaches to understand the roles of DNA methylation and hydroxymethylation in neurodevelopment and cancer

Key words
bioinformatics, cancer, cancer genomics, epigenetics, epigenomics, neurodevelopment, transcriptional regulation

Program affiliation
Human and Statistical Genetics
Molecular Microbiology and Microbial Pathogenesis

Research summary
Asking and answering critical questions to guide clinical practice and ameliorate childhood suffering due to staphylococcal disease

Key words
Staphylococcus aureus; antibiotic resistance; epidemiology; infection treatment and prevention; genomic determinants of disease; host immune response

Program affiliation
Biomedical Informatics and Data Science
Human and Statistical Genetics
Computational and Systems Biology

Research summary
Statistical genetics and bioinformatics, high-dimensional data analysis and complex systems modeling, developing novel methodologies for detecting complex disease genes and characterizing their function

Key words
genetic epidemiology, statistical genetics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

Program affiliation
Human and Statistical Genetics
Biomedical Informatics and Data Science

Research summary
Genetic studies of alcoholism, smoking and drug dependence, depression, suicidality and anxiety disorders, personality disorders, and methodological research in genetic epidemiology

Key words
substance abuse, development, modeling, psychiatry, quantitative genetics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Cancer prevention and control, health disparities and community-based research

Key words

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Integration of whole-genome sequence with phenotypic data to understand parent-of-origin genetic effects and gene-by-environment interactions

Key words
Epigenetics, gene regulation, parent-of-origin effects, gene-by-environment interactions, pleiotropy, systems biology, metabolism, evolution

Program affiliation
Cancer Biology
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Translational Cancer Genomics; Noncoding RNAs

Key words
non-coding RNAs, lncRNAs, cancer genomics, transcriptome, bioinformatics, computational biology, solid tumor malignancies

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Mathematical development of new statistical genetics methodology for complex traits

Key words
biostatistics, genetic epidemiology, human genetics, mathematical modeling, statistical genetics, systems biology

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Using bench molecular biology, high-throughput sequencing, and bioinformatics to understand human inflammatory / autoimmune disease.

Key words
human genetics; autoimmune; inflammatory disease; biomarkers; high-throughput sequencing; precision medicine