Computational and Systems Biology

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics
Neurosciences

Research summary
Discovery and characterization of genetic etiological factors involved in neurodevelopmental disorders

Key words
genomics, genetics, autism, neurodevelopmental disorders, complex disease, noncoding, enhancers, whole-genome sequencing, whole-exome sequencing, single-nucleotide variation, insertions/deletions, copy number variation, structural variation

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology

Research summary
Our lab investigates how non-coding genetic variation controls developmental programs and contributes to human disease and evolutionary change. We focus on congenital structural anomalies, pregnancy complications, and bat wing development, combining mouse genetics, embryo genome engineering, and functional genomics approaches, including in vivo MPRAs, to functionally dissect regulatory elements.

Key words
Enhancers, non-coding regulatory variation, developmental genetics, evolution, GWAS, limb development, placental biology, craniofacial development, functional genomics, MPRA

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Discovery and Characterization of Novel Viruses

Key words
microbial pathogenesis, functional genomics, virology, genome analysis, computational biology

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Epigenome evolution and epigenetic determinants of cell fate

Key words
DNA methylation, transposable elements, epigenomics, evolution, genomics, systems biology

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Elucidating human brain connectivity during different states of arousal, across the lifespan, and in health and disease.

Key words

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology

Research summary
My lab seeks to understand how DNA sequence determines its regulatory function. We combine functional genomic technologies with deep learning models to answer this question.

Key words
computational biology, gene regulation, genomics, deep learning, technology development

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
We investigate the interplay among the microbiota, stromal cells, and the immune system through the integration of microbiology and immunology with systems biology.

Key words
Microbiota, Microbiome, Immune system, Stromal cells, Vaccines, Germinal Centers

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Host-microbe dynamics during pregnancy

Key words
virome, microbiome, pregnancy, papillomavirus, herpesvirus

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Developmental Regenerative and Stem Cell Biology

Research summary

Key words
Bioinformatics, epigenetics