Molecular Cell Biology

Program affiliation
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the mechanism mediating intravascular cell-cell interactions and vascular occlusion under thromboinflammatory conditions, including thrombosis, ischemia/reperfusion injury, and sickle cell disease

Key words
Platelet, Neutrophil, Thrombosis, Inflammation, Sickle Cell Disease, Intravital microscopy

Program affiliation
Immunology
Molecular Cell Biology
Cancer Biology

Research summary
Understanding T cells and immunoregulatory networks in GvHD and GvL for the treatment of hematopoietic malignancies.

Key words
graft-versus-host disease (GvHD), graft-versus-leukemia (GvL), JAK-STAT, immune cell trafficking, transplant immunology, CRISPR/Cas9

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Cancer Biology
Molecular Cell Biology

Research summary
Angioimmune interface in development, tissue regeneration, and cancer

Key words
Cell fate, transcription factors, hematopoiesis, vascular, development, regeneration, stem cells, tumor angiogenesis, tumor immunity

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Our current research focuses on delineating the cellular, molecular, and metabolic processes involved in the development of fibrotic disorders such as Idiopathic pulmonary fibrosis (IPF) and how these metabolic adaptations may in turn be targeted therapeutically for IPF.

Key words
Idiopathic pulmonary fibrosis (IPF), metabolic networks, targetable mechanisms driving fibroblast function and fibrosis

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Improve outcomes for patients with acute myeloid leukemia (AML) and other hematopoietic malignancies utilizing genomic and molecular biology techniques

Key words

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Cancer Biology

Research summary
Connexins, cadherins in bone cell interactions with cancer and energy metabolism

Key words
bone biology, cell adhesion, signal transduction, gap junctions, cadherin

Program affiliation
Immunology
Molecular Cell Biology

Research summary
The mechanisms regulating calcium-dependent neutrophil activation

Key words

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding extracellular vesicle (EV)-mediated signaling during homeostatic and pathologic metabolic regulation

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
My lab aims to establish the fundamental principles of intracellular physical chemistry and electrochemical functions of macromolecular complexes, and design synthetic proteins as therapeutics for condensate-dependent diseases.

Key words
molecular biology; physical chemistry; biochemistry; biophysics; synthetic biology; electrochemistry; phase transition; condensates

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My research aims to understand the lung vascular homeostasis and the pathogenesis of pulmonary diseases using novel animal models, integrated pharmacological approaches, genome editing and single cell RNA-sequencing and spatial transcriptomics.

Key words
cardiovascular, lung, vascular, single cell, spatial transcriptomic