Molecular Cell Biology

Program affiliation
Immunology
Molecular Cell Biology

Research summary
Our laboratory is interested in the role of platelets and leukocytes in inflammatory diseases which induce changes in hemostasis and thrombosis

Key words
thrombosis, platelets, stroke, neutrophils

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
We study disease-relevant cell and organ signaling pathways in inflammatory bowel disease using molecular and cell biology, multi-omics technologies, genetic murine models, and patient samples.

Key words
inflammatory bowel disease, mucosal immunity, innate lymphoid cells, human intestinal organoids, regenerative medicine, biomarker discovery, cellular stress response, perianal fistulizing Crohn's disease, eosinophilic esophagitis, colon cancer

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Cellular, Molecular and Epigenetic control of axon regeneration

Key words
axon regeneration, nerve injury, epigenetic, transcription, glia biology, neuroimmune mechanisms, spinal cord injury, optic nerve injury

Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells

Key words
Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology

Research summary
Mechanisms and Design Principles of Ion Channel Function and Gating

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences

Research summary
Characterizing and dissecting the molecular mechanisms of opioid receptor signaling

Key words
GPCRs, Analgesics, Side effects, opioid receptors, opioids, opioid alternatives

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
The Chen lab utilizes multi-omic and high-throughput screening approaches to investigate the regulation and function of circRNA and uncover the molecular mechanisms of circRNA-mediated disease.

Key words
Circular RNA, Oxidative Stress, RNA Translation, Cancer Vaccine

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Identifying new therapeutic targets of small cell lung cancer

Key words
Lung cancer, DNA damage repair, immunology, drug resistance, genetic screening, translational research, drug development, targeted therapy, precision therapy

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals

Key words
neuromodulator, sleep, dynamics, sensors, actuators, signaling, G protein coupled receptors, imaging, microscopy, learning, plasticity, engineering