Molecular Cell Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Biochemistry of malaria

Key words
biochemistry, metabolism, parasitology, malaria, protease, heme, aspartic

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Computational mass spectrometry and proteomics

Key words
Mass Spectrometry, Proteomics, Bioinformatics

Program affiliation
Immunology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Our research is dedicated to investigating the immunobiological pathways that underlie such pregnancy complications, with a special emphasis on preterm birth.

Key words
Immunology of Pregnancy, Maternal-fetal Immunology, In utero Inflammation, Preterm Birth

Program affiliation
Molecular Cell Biology
Neurosciences

Research summary

Key words

Program affiliation
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics

Research summary
Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Role of the human gut microbiome in health and disease, notably childhood undernutrition and obesity

Key words
Gut microbiome; systems biology; postnatal development; childhood malnutrition; global health; gnotobiotic animal models; metabolic regulation; food webs; gut-brain axis; gut barrier/immune function; microbiome-targeted therapeutics

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Relationship of structure to function in allosteric control mechanisms

Key words
protein structure, protein function, allosteric regulation, enzymology, biochemistry

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Our lab works on endogenous etiologies of mutagenesis and genome instability in pediatric cancers

Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
My long-term research interest focuses on the generation and transduction of mechanical forces in cardiovascular disease. In particular, my lab utilizes an array of biophysical, biochemical, cell biological, and engineering techniques to decipher how mutations associated with familial cardiomyopathies drive disease pathogenesis at the molecular, cellular, and tissue levels. My lab is also working to develop precision medicine approaches for pediatric and adult heart failure.

Key words
single molecule, biophysics, heart disease, myosin, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine