Molecular Cell Biology
Abby M. Green, MD
Associate Professor
- Email: abby.green@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Our lab works on endogenous etiologies of mutagenesis and genome instability in pediatric cancers
Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis
Michael J. Greenberg, PhD
Professor
- Email: greenberg@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
My long-term research interest focuses on the generation and transduction of mechanical forces in cardiovascular disease. In particular, my lab utilizes an array of biophysical, biochemical, cell biological, and engineering techniques to decipher how mutations associated with familial cardiomyopathies drive disease pathogenesis at the molecular, cellular, and tissue levels. My lab is also working to develop precision medicine approaches for pediatric and adult heart failure.
Key words
single molecule, biophysics, heart disease, myosin, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine
Eric Greer, PhD
Associate Professor
- Email: ericg@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise
Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics
Obi L. Griffith, PhD
Professor
- Email: obigriffith@wustl.edu
Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Cell Biology
Immunology
Research summary
Development of personalized medicine strategies for cancer using genomic technologies
Key words
bioinformatics, machine learning, cancer, genomics, immunogenomics, precision oncology
Andy Groves, PhD
Stuart A. Kornfeld Distinguished Professor and Head of the Department of Developmental Biology
- Email: groves.a@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Molecular Cell Biology
Research summary
We work on what induces the inner ear in the first place, how the sensory organs of the ear acquire their exquisite pattern, and whether it will ever be possible to regenerate the sensory hair cells of the inner ear in the deaf and hard-of-hearing.
Key words
inner ear, development, regeneration, sensory neuroscience, balance, deafness, embryo, transcription factors, epigenetics, tunicates, squid
Caroline Guglielmetti, PhD
Assistant Professor
Program affiliation
Neurosciences
Molecular Cell Biology
Immunology
Research summary
We develop innovative magnetic resonance (MR) and position emission tomography (PET) imaging approaches to monitor neuroinflammation, neurodegeneration and repair mechanisms in neurological disorders
Key words
Metabolic imaging, hyperpolarized 13C MRI, positron tomography emission (PET) imaging, neurological disorders, cell tracking, multiple sclerosis, microglia, myelin, immune cells
Farshid Guilak, PhD
Mildred B. Simon Research Professor
- Email: guilak@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology
Research summary
Application of stem cells and mechanobiology in the onset, progression, and treatment of osteoarthritis and other joint diseases.
Key words
cartilage, obesity, osteoarthritis, mechanobiology, bioengineering, stem cells, iPSCs
Carmen Halabi, MD, PhD
Associate Professor
- Email: chalabi@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease
Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension
Dennis E. Hallahan, MD
Professor and Head of the Department of Radiation Oncology
- Email: dhallahan@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Research summary
The mechanisms of cell death in normal tissues during cancer therapy
Key words
cancer, cell death, drug delivery, radiation, signal transduction
Jeffrey Haspel, MD, PhD
Associate Professor
- Email: jhaspel@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease
Key words