Molecular Genetics and Genomics
Robi Mitra, PhD
Alvin Goldfarb Professor of Computational Biology
- Email: rmitra@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Research summary
Technology development for functional genomics and systems biology
Key words
functional genomics, systems biology, technology development, bioinformatics
Makedonka Mitreva, PhD
Professor
- Email: mmitreva@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome
Key words
Genomics of Infectious Diseases, Helminth Genomics, Human Metagenomics
Mayssa Mokalled, PhD
Associate Professor
- Email: mmokalled@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Research summary
Mechanisms of neural regeneration using zebrafish and mouse model systems
Key words
Nima Mosammaparast, MD, PhD
Associate Professor
- Email: nima@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding how RNA modifications influence transcription, signaling, and genomic integrity
Key words
RNA modifications, cancer , transcription, DNA repair
Brian Muegge, MD, PhD
Assistant Professor
- Email: mueggeb@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology
Research summary
Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases
Key words
Genomics, Single-Cell, Endocrinology, Stem Cells, Gastroenterology, Intestine, Epigenetics
Natalie Niemi, PhD
Assistant Professor
- Email: niemi@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
Understanding how mitochondria are built, regulated, and maintained
Key words
mitochondria, phosphorylation, metabolism, signaling, kinase, phosphatase
Regis O`Keefe, MD, PhD
Fred C Reynolds Professor and Head of the Department of
- Email: rokeefe@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone
Key words
Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone
Stephen Oh, MD, PhD
Samuel B. Grant Professor
- Email: stoh@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Research summary
Mechanisms of dysregulated signaling in blood cancers
Key words
cancer biology, signal transduction, JAK2, leukemia, hematopoiesis, stem cells, mass cytometry, CyTOF, genomics
Dave Pagliarini, PhD
Hugo F. and Ina C. Urbauer Professor
- Email: pagliarini@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.
Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry
Himadri Pakrasi, PhD
George William and Irene Koechig Freiberg Professor
- Email: pakrasi@wustl.edu
Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
Systems and Synthetic Biology of photosynthetic organisms
Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology