Molecular Genetics and Genomics
Jacqueline Payton, MD, PhD
Associate Professor
- Email: jpayton@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Biomedical Informatics and Data Science
Molecular Microbiology and Microbial Pathogenesis
Research summary
Epigenomic aberrations in B cell lymphomas and their impact on gene regulation
Key words
epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation
Toby Pennington, DPhil
David and Dorothy Kemper Professor
- Email: ptoby@wustl.edu
Program affiliation
Ecology and Evolutionary Biology
Molecular Genetics and Genomics
Plant and Microbial Biosciences
Research summary
Key words
Toby Pennington, D.Phil
David and Dorothy Kemper Professor
- Email: ptoby@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Plant and Microbial Biosciences
Research summary
Key words
David Perlmutter, MD
Spencer T. and Ann W. Olin Distinguished Professor
- Email: perlmutterd@wustl.edu
Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics
Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins
Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs
Jennifer Phillips-Cremins, PhD
BJC Investigator and James S. McDonnell Professor
- Email: jennifer.cremins@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.
Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids
Elizabeth Ann Pollina, PhD
Assistant Professor
- Email: pollina@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation
Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation
Sidharth Puram, MD, PhD
Lindburg Professor and Head of the Department of Otolaryngology
- Email: sidpuram@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics
Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling
Lee Ratner, MD, PhD
Professor
- Email: lratner@wustl.edu
Program affiliation
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Research summary
Molecular biology and pathogenesis of HIV and HTLV
Key words
lymphocytes, virology, AIDS, leukemia, HIV, HTLV, NF kB
Michael Rauchman, MDCM
Professor
- Email: mrauchma@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Investigate gene regulation during kidney development and disease
Key words
Linda Richards, AO, FAA, FAHMS, PhD
Edison Professor of Neuroscience & Head of the Department of Neuroscience
- Email: neurosciencechair@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology
Research summary
The Brain Development and Disorders Laboratory investigates how long-range neural circuits are established in the brain, and how neural circuit plasticity affects the function of the cerebral cortex.
Key words
cognitive and behavioral neuroscience, developmental neurobiology, molecular and cellular neuroscience, neurogenetics, cerebral cortex, corpus callosum, glial development, neuronal development, brain wiring, agenesis