Molecular Genetics and Genomics
Stephen Oh, MD, PhD
Samuel B. Grant Professor
- Email: stoh@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Research summary
Mechanisms of dysregulated signaling in blood cancers
Key words
cancer biology, signal transduction, inflammation, JAK2, leukemia, hematopoiesis, stem cells, genomics
Dave Pagliarini, PhD
Hugo F. and Ina C. Urbauer Professor
- Email: pagliarini@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.
Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry
Himadri B. Pakrasi, PhD
George William and Irene Koechig Freiberg Professor
- Email: pakrasi@wustl.edu
Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
Systems and Synthetic Biology of photosynthetic organisms
Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology
Jacqueline Elise Payton, MD, PhD
Associate Professor
- Email: jpayton@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Biomedical Informatics and Data Science
Molecular Microbiology and Microbial Pathogenesis
Research summary
Epigenomic aberrations in B cell lymphomas and their impact on gene regulation
Key words
epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation
Toby Pennington, D.Phil
David and Dorothy Kemper Professor
- Email: ptoby@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Plant and Microbial Biosciences
Research summary
Key words
David H. Perlmutter, MD
Spencer T. and Ann W. Olin Distinguished Professor
- Email: perlmutterd@wustl.edu
Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics
Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins
Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs
Jennifer E. Phillips-Cremins, PhD
BJC Investigator and James S. McDonnell Professor
- Email: jennifer.cremins@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.
Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids
Elizabeth Ann Pollina, PhD
Assistant Professor
- Email: pollina@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation
Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation
Sid Puram, MD, PhD
Lindburg Professor and Chair of the Department of Otolaryngology
- Email: sidpuram@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the role of tumor heterogeneity in cancer biology using single cell and spatial techniques, with an emphasis on how tumor subpopulations (malignant, stromal, and immune cells) drive cancer development, growth, metastasis, and treatment resistance. We are particularly focused on how to translate these insights into new diagnostics and novel therapeutics.
Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling
Gwendalyn J Randolph, PhD
Emil R. Unanue Distinguished Professor
- Email: gjrandolph@wustl.edu
Program affiliation
Immunology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Research summary
We focus on inter-organ communication and the transit of cells and molecules out of tissues in healthy and disease states
Key words
lymphatic vessels, lymph nodes, IBD, monocytes, macrophages, high-density lipoprotein, peritoneal tumor metastasis, peritoneal macrophages