Molecular Genetics and Genomics
Ryan B. Day, MD, PhD
Assistant Professor
- Email: ryanday@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
My lab is interested in understanding how dysregulation of the Core Binding Factor transcription factor promotes AML development
Key words
hematopoiesis, leukemia, AML, acute myeloid leukemia, CBF, RUNX1, CBFB, core binding factor
Jorge Di Paola, MD
Professor/Division Chief
- Email: dipaolaj@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
The genetics of bleeding and thrombotic disorders and mechanisms of platelet activation
Key words
Patricia I. Dickson, MD
Centennial Professor
- Email: pdickson@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Research summary
Developing therapies and studying the impact of lysosomal storage disorders in animal models and in trials
Key words
Li Ding, PhD
David English Smith Distinguished Professor
- Email: lding@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Cancer Proteogenomics and Cancer Models
Key words
Anita Donlic, PhD
Assistant Professor
- Email: donlic@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
Cells are not just bags of molecules - they organize their biochemistry in space, often using dynamic compartments called biomolecular condensates. Our lab is asking fundamental questions about the role of condensates in biology, such as: how do condensate environments influence RNA recognition and metabolism? How do they alter the activity of therapeutics? And how do they contribute to oncogenic cell states? We do this using interdisciplinary approaches spanning chemical biology, quantitative cell microscopy, in vitro biophysics, and machine learning. We hope to ultimately uncover how subcellular organization shapes cellular function and how these principles can be harnessed therapeutically.
Key words
condensates, RNA, chemical biology, therapeutics, microscopy, cancer
Joseph D. Dougherty, PhD
Professor
- Email: jdougherty@wustl.edu
Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology
Human and Statistical Genetics
Research summary
Human Psychiatric Genetics, Mouse Models, Cell Type Specific Gene Expression Profiling, Translation, Astrocytes.
Key words
autism, gene expression profiling, genetics, genomics, mouse models, neurobiology, astrocytes, translation regulation
Bettina F. Drake, PhD, MPH
Assistant Professor
- Email: drakeb@wustl.edu
Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Cancer Biology
Research summary
Identifying preventive strategies to reduce cancer disparities
Key words
Susan K. Dutcher, PhD
Professor
- Email: dutcher@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Molecular Cell Biology
Human and Statistical Genetics
Plant and Microbial Biosciences
Research summary
The lab investigates the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology in Chlamydomonas as well as human tissue culture cells. The key questions that we address are: 1.) how these microtubule-based structures are assembled, and 2.) how they function and influence cellular biology, development, and human health. Our interest in basal bodies/cilia led us to use bioinformatics and comparative genomics.
Key words
centrioles, cilia, signal transduction, cytoskeleton, lung disease
Brian T. Edelson, MD, PhD
Associate Professor
- Email: bedelson@wustl.edu
Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Research summary
Immune cell development and function
Key words
dendritic cells, macrophages, hematopoiesis, infection, inflammation, innate immunity, autoimmunity, multiple sclerosis
John R. Edwards, PhD
Associate Professor
- Email: jredwards@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Research summary
We develop new computational and experimental approaches to understand the roles of DNA methylation and hydroxymethylation in neurodevelopment and cancer
Key words
bioinformatics, cancer, cancer genomics, epigenetics, epigenomics, neurodevelopment, transcriptional regulation