Molecular Genetics and Genomics

Program affiliation
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology

Research summary

Key words

Program affiliation
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics

Research summary
Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
The etiology of mutagenesis and genome instability in pediatric cancers

Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise

Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We work on what induces the inner ear in the first place, how the sensory organs of the ear acquire their exquisite pattern, and whether it will ever be possible to regenerate the sensory hair cells of the inner ear in the deaf and hard-of-hearing.

Key words
inner ear, development, regeneration, sensory neuroscience, balance, deafness, embryo, transcription factors, epigenetics, tunicates, squid

Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
Leveraging neurogenetic disorders to study normal brain development, cancer, and autism

Key words
pediatric brain cancer, brain development, neuroimmunology, cancer neuroscience, autism, hiPSC engineering, genetically engineered mice

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease

Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences

Research summary
Genetic underpinnings of neurological/neurosurgical disorders

Key words
rare variants, Chiari I malformation, human genetics, neurosurgery, Deep Mutation Scanning, Mutagenesis, Limb-girdle muscular dystrophy

Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics. 

Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration