Molecular Genetics and Genomics

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Cellular and molecular pathogenesis of Alzheimer's disease

Key words
Alzheimer's disease, neurodegeneration, amyloid, tau, mouse models, risk factors, lysosome, gene therapy

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary

Key words

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Molecular Cell Biology

Research summary
We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying human disease

Key words
Functional genomics, bioinformatics, human genetics, data science, rare diseases, structural variation

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Immunology

Research summary
Molecular mechanisms of skeletal and cardiac muscle development and disease

Key words
muscle, congenital disease, organogenesis, gene discovery

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Genetics and Genomics

Research summary
We are broadly interested in understanding host/pathogen interactions in malaria parasites. We use a range of approaches including biochemistry, red blood cell genetics and parasite genetics to identify essential ligand/receptor interactions in malaria parasites, with the long-term goal of developing novel therapeutics.

Key words
malaria, red blood cell, plasmodium, ligand/receptor

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary

Key words
tumor growth, metastasis, signaling mechanisms, immunology, cancer, B cells, Tregs

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Microbial community-immune interactions in airway diseases and urogenital tract

Key words
microbiota; microbiome; mucosal immunity; asthma; allergy; atopy; urinary tract infection; pathogen colonization; metabolomics;

Program affiliation
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease

Key words
melanoma, cancer initiation, epigenetics, molecular genetics, neural crest, zebrafish, cancer models

Program affiliation
Neurosciences
Molecular Genetics and Genomics

Research summary
In the Kautt Lab, we combine a genomics-centered approach with molecular experiments, behavioral assays, and fieldwork to elucidate both the evolutionary and molecular mechanisms underlying organismal adaptation and diversification, with a focus on animal behavior.

Key words
Evolution, Genomics, Behavior, Adaptation, Speciation

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
clinical and translational research in gynecologic oncology, with a focus on ovarian cancer

Key words