Zach Papadopoulos

Program: Neurosciences

Current advisor: Jonathan Kipnis, PhD

Undergraduate university: Colgate University, 2017

Enrollment year: 2020

Research summary

Graduate publications
Smyth LCD, Xu D, Okar SV, Dykstra T, Rustenhoven J, Papadopoulos Z, Bhasiin K, Kim MW, Drieu A, Mamuladze T, Blackburn S, Gu X, Gaitán MI, Nair G, Storck SE, Du S, White MA, Bayguinov P, Smirnov I, Dikranian K, Reich DS, Kipnis J. 2024 Identification of direct connections between the dura and the brain. Nature, 627(8002):165-73. PMCID: PMC11254388

Xu W, Rustenhoven J, Nelson CA, Dykstra T, Ferreiro A, Papadopoulos Z, Burnham CD, Dantas G, Fremont DH, Kipnis J. 2023 A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan. Neuron, 111(20):3244-54. PMCID: PMC10592285

Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, Chhatwal J; Dominantly Inherited Alzheimer Network; Hu S, Randolph GJ, Smirnov I, Kipnis J. 2022 Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature, 611(7936):585-593. PMCID: PMC9899827

Herz J, Fu Z, Kim K, Dykstra T, Wall M, Li H, Salvador AF, Zou B, Yan N, Blackburn SM, Andrews PH, Goldman DH, Papadopoulos Z, Smirnov I, Xie XS, Kipnis J. 2021 GABAergic neuronal IL-4R mediates T cell effect on memory. Neuron, 109(22):3609-3618.e9. PMCID: PMC9116260

Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J. 2021 Functional characterization of the dural sinuses as a neuroimmune interface. Cell, 184(4):1000-1016.e27. PMCID: PMC8487654

Cugurra A, Mamuladze T, Rustenhoven J, Dykstra T, Beroshvili G, Greenberg ZJ, Baker W, Papadopoulos Z, Drieu A, Blackburn S, Kanamori M, Brioschi S, Herz J, Schuettpelz LG, Colonna M, Smirnov I, Kipnis J. 2021 Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science, 373(6553):eabf7844. PMCID: PMC8863069

Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS; Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J. 2021 Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature, 593(7858): 255-60. PMCID: PMC8817786

Papadopoulos Z, Herz J, Kipnis J. 2020 Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance. J Immunol, 204(2):286-93

Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, Martelossi Cebinelli G, Mamuladze T, Baker W, Papadopoulos Z, Lopes MB, Cao WS, Xie XS, Herz J, Kipnis J. 2020 Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol, 11(1):1421-29. PMCID: PMC8496952

Kang R, Kim K, Jung Y, Choi SH, Lee C, Im GH, Shin M, Ryu K, Choi S, Yang E, Shin W, Lee S, Lee S, Papadopoulos Z, Ahn JH, Koh GY, Kipnis J, Kang H, Kim H, Cho WK, Park S, Kim SG, Kim E. Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice. PLoS Biol, 22(5):e3002596. PMCID: PMC11104772